Inorganic polyphosphate in mammals: where's Wally?
cell metabolism
inorganic polyphosphates
phosphate
post translational modification
signalling
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
28 02 2020
28 02 2020
Historique:
received:
23
10
2019
revised:
20
01
2020
accepted:
21
01
2020
pubmed:
13
2
2020
medline:
9
4
2020
entrez:
13
2
2020
Statut:
ppublish
Résumé
Inorganic polyphosphate (polyP) is a ubiquitous polymer of tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. In prokaryotes and lower eukaryotes, both the presence of polyP and of the biosynthetic pathway that leads to its synthesis are well-documented. However, in mammals, polyP is more elusive. Firstly, the mammalian enzyme responsible for the synthesis of this linear biopolymer is unknown. Secondly, the low sensitivity and specificity of available polyP detection methods make it difficult to confidently ascertain polyP presence in mammalian cells, since in higher eukaryotes, polyP exists in lower amounts than in yeast or bacteria. Despite this, polyP has been given a remarkably large number of functions in mammals. In this review, we discuss some of the proposed functions of polyP in mammals, the limitations of the current detection methods and the urgent need to understand how this polymer is synthesized.
Identifiants
pubmed: 32049314
pii: 222097
doi: 10.1042/BST20190328
pmc: PMC7054745
doi:
Substances chimiques
Polyphosphates
0
Phosphotransferases (Phosphate Group Acceptor)
EC 2.7.4.-
polyphosphate kinase
EC 2.7.4.1
Phospholipase D
EC 3.1.4.4
Acid Anhydride Hydrolases
EC 3.6.-
endopolyphosphatase
EC 3.6.1.10
exopolyphosphatase
EC 3.6.1.11
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-101Subventions
Organisme : Medical Research Council
ID : MC_UU_12018/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00012/4
Pays : United Kingdom
Informations de copyright
© 2020 The Author(s).
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