Postinfectious bronchiolitis obliterans masked by misdiagnosis as asthma.
Adenoviridae Infections
Adolescent
Aged
Asthma
/ diagnosis
Bronchiolitis Obliterans
/ diagnosis
Child
Child, Preschool
Diagnosis, Differential
Diagnostic Errors
/ adverse effects
Disease Susceptibility
/ complications
Female
Humans
Infant
Male
Middle Aged
Respiratory Function Tests
Retrospective Studies
asthma
children
postinfectious bronchiolitis obliterans
Journal
Pediatric pulmonology
ISSN: 1099-0496
Titre abrégé: Pediatr Pulmonol
Pays: United States
ID NLM: 8510590
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
28
11
2019
accepted:
04
02
2020
pubmed:
13
2
2020
medline:
21
10
2020
entrez:
13
2
2020
Statut:
ppublish
Résumé
Asthma and postinfectious bronchiolitis obliterans (PIBO) have similar clinical findings, and PIBO may be misdiagnosed with asthma. This study aimed to determine the clinical features of PIBO in children and the causes of delay in its diagnosis. We retrospectively evaluated all patients diagnosed with PIBO in four pediatric pulmonology centers between 2007 and 2018. In total, 64 PIBO patients were retrospectively reviewed. We compared the clinical and laboratory differences between PIBO patients who had initially been misdiagnosed with asthma and correctly diagnosed with PIBO. Of the 64 patients, 22 (34.4%) had initially been misdiagnosed with asthma. Adenovirus was the most common infectious agent in children. The age upon diagnosis was older, and the symptom duration was significantly longer in patients misdiagnosed with asthma (P < .05). There were no statistical differences in terms of sex, history of prematurity, duration of hospitalization, treatment, history of oxygen or mechanical ventilation support, pulmonary function test (PFT) results and asthma-predisposing findings between the two groups (P > .05). Patients with PIBO who had initially been misdiagnosed with asthma were correctly diagnosed at older ages and had longer symptom duration. Asthma may mask PIBO diagnosis by the similarity of symptoms and the clinical response to inhaled β2-agonist or steroid treatment. PFTs may not help clinicians because of the age of children. The delay in the diagnosis of PIBO is probably attributable to the fact that some clinicians fail to include PIBO in the differential diagnosis when there is no clinical response to asthma medication.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1007-1011Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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