Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in
Amino Acid Sequence
Animals
Animals, Genetically Modified
Chondroitin Sulfate Proteoglycans
/ physiology
Chondroitin Sulfates
/ metabolism
Drosophila Proteins
/ genetics
Drosophila melanogaster
/ genetics
Female
Gene Expression Regulation, Developmental
Gene Knockdown Techniques
Hedgehog Proteins
/ physiology
Heparitin Sulfate
/ metabolism
Imaginal Discs
/ metabolism
Larva
Membrane Proteins
/ genetics
RNA Interference
RNA, Small Interfering
/ genetics
Signal Transduction
/ physiology
Wings, Animal
/ growth & development
Journal
Molecular biology of the cell
ISSN: 1939-4586
Titre abrégé: Mol Biol Cell
Pays: United States
ID NLM: 9201390
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
pubmed:
13
2
2020
medline:
3
6
2021
entrez:
13
2
2020
Statut:
ppublish
Résumé
Proteoglycans, a class of carbohydrate-modified proteins, often modulate growth factor signaling on the cell surface. However, the molecular mechanism by which proteoglycans regulate signal transduction is largely unknown. In this study, using a recently developed glycoproteomic method, we found that Windpipe (Wdp) is a novel chondroitin sulfate proteoglycan (CSPG) in
Identifiants
pubmed: 32049582
doi: 10.1091/mbc.E19-06-0327
pmc: PMC7185963
doi:
Substances chimiques
Chondroitin Sulfate Proteoglycans
0
Drosophila Proteins
0
Hedgehog Proteins
0
Membrane Proteins
0
RNA, Small Interfering
0
wdp protein, Drosophila
0
hh protein, Drosophila
149291-21-4
Chondroitin Sulfates
9007-28-7
Heparitin Sulfate
9050-30-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
813-824Subventions
Organisme : NIH HHS
ID : P40 OD010949
Pays : United States
Organisme : NIH HHS
ID : P40 OD018537
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131688
Pays : United States
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