Case-Control Study of Paresthesia Among World Trade Center-Exposed Community Members.
Journal
Journal of occupational and environmental medicine
ISSN: 1536-5948
Titre abrégé: J Occup Environ Med
Pays: United States
ID NLM: 9504688
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
13
2
2020
medline:
1
5
2021
entrez:
13
2
2020
Statut:
ppublish
Résumé
To investigate whether paresthesia of the lower extremities following exposure to the World Trade Center (WTC) disaster was associated with signs of neuropathy, metabolic abnormalities, or neurotoxin exposures. Case-control study comparing WTC-exposed paresthesia cases with "clinic controls" (WTC-exposed subjects without paresthesias), and "community controls" (WTC-unexposed persons). Neurological histories and examination findings were significantly worse in cases than controls. Intraepidermal nerve fiber densities were below normal in 47% of cases and sural to radial sensory nerve amplitude ratios were less than 0.4 in 29.4%. Neurologic abnormalities were uncommon among WTC-unexposed community controls. Metabolic conditions and neurotoxin exposures did not differ among groups. Paresthesias among WTC-exposed individuals were associated with signs of neuropathy, small and large fiber disease. The data support WTC-related exposures as risk factors for neuropathy, and do not support non-WTC etiologies.
Identifiants
pubmed: 32049876
doi: 10.1097/JOM.0000000000001828
pmc: PMC7113112
mid: NIHMS1553939
pii: 00043764-202004000-00009
doi:
Substances chimiques
Dust
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
307-316Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES000260
Pays : United States
Organisme : NIOSH CDC HHS
ID : U01 OH011305
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001445
Pays : United States
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