Cholesterol-Lowering Action of a Novel Nutraceutical Combination in Uremic Rats: Insights into the Molecular Mechanism in a Hepatoma Cell Line.
Acyl Coenzyme A
/ metabolism
Adenine
Animals
Anticholesteremic Agents
Cell Line, Tumor
Cholesterol
/ biosynthesis
Cysteine
/ analogs & derivatives
Dietary Supplements
Humans
Hypercholesterolemia
/ etiology
Iron
Magnesium
Male
Rats, Sprague-Dawley
Receptors, LDL
/ metabolism
Renal Insufficiency, Chronic
/ complications
Simvastatin
Uremia
/ complications
Vascular Calcification
MK-7
PCSK9
cholesterol
mevalonate pathway
uremic
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
09 Feb 2020
09 Feb 2020
Historique:
received:
10
01
2020
revised:
05
02
2020
accepted:
06
02
2020
entrez:
14
2
2020
pubmed:
14
2
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Appropriate nutraceutical combinations may represent a valid approach to prevent vascular calcification associated with chronic kidney disease (CKD). In the present study, we tested the effect of a new nutraceutical combination named RenaTris
Identifiants
pubmed: 32050453
pii: nu12020436
doi: 10.3390/nu12020436
pmc: PMC7071245
pii:
doi:
Substances chimiques
Acyl Coenzyme A
0
Anticholesteremic Agents
0
Receptors, LDL
0
magnesium carbonate
0E53J927NA
3-hydroxy-3-methylglutaryl-coenzyme A
1553-55-5
alliin
7I4L2D0E9G
Cholesterol
97C5T2UQ7J
Simvastatin
AGG2FN16EV
Iron
E1UOL152H7
Magnesium
I38ZP9992A
Adenine
JAC85A2161
Cysteine
K848JZ4886
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
E.B. and G.T. are employees at PharmaNutra S.p.A.; N.F., M.P.A., M.G.L., N.B., G.V., M.S., S.S., C.N., H.C., A.B., E.F., M.R., and S.D.A. do not have any conflicts of interest to declare.
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