Antimicrobial Locks in Patients Receiving Home Parenteral Nutrition.
antimicrobial lock therapy
biofilm
catheter salvage
catheter-related bloodstream infection
home parenteral nutrition
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
10 Feb 2020
10 Feb 2020
Historique:
received:
08
01
2020
revised:
02
02
2020
accepted:
03
02
2020
entrez:
14
2
2020
pubmed:
14
2
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Catheter-related bloodstream infection (CRBSI) is one of the most common and potentially fatal complications in patients receiving home parenteral nutrition (HPN). In order to prevent permanent venous access loss, catheter locking with an antimicrobial solution has received significant interest and is often a favored approach as part of the treatment of CRBSI, but mainly for its prevention. Several agents have been used for treating and preventing CRBSI, for instance antibiotics, antiseptics (ethanol, taurolidine) and, historically, anticoagulants such as heparin. Nonetheless, current guidelines do not provide clear guidance on the use of catheter locks. Therefore, this review aims to provide a better understanding of the current use of antimicrobial locking in patients on HPN as well as reviewing the available data on novel compounds. Despite the fact that our current knowledge on catheter locking is still hampered by several gaps, taurolidine and ethanol solutions seem promising for prevention and potentially, but not proven, treatment of CRBSI. Additional studies are warranted to further characterize the efficacy and safety of these agents.
Identifiants
pubmed: 32050544
pii: nu12020439
doi: 10.3390/nu12020439
pmc: PMC7071146
pii:
doi:
Substances chimiques
Anti-Infective Agents
0
Solutions
0
Thiadiazines
0
Taurine
1EQV5MLY3D
Ethanol
3K9958V90M
taurolidine
8OBZ1M4V3V
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
Dane Christina Daoud has no financial relationships and competing interests relevant to this publication to disclose.
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