Changes in the Transmission Dynamic of Chikungunya Virus in Southeastern Senegal.
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Antibodies, Viral
/ blood
Chikungunya Fever
/ epidemiology
Child
Child, Preschool
Environment
Female
Forests
Humans
Immunoglobulin G
/ blood
Infant
Male
Middle Aged
Mining
Population Density
Rural Population
/ statistics & numerical data
Senegal
/ epidemiology
Seroepidemiologic Studies
Young Adult
Chikungunya
Senegal
environmental risk
gold mining
spatial autocorrelation
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
10 02 2020
10 02 2020
Historique:
received:
23
10
2019
revised:
02
01
2020
accepted:
24
01
2020
entrez:
14
2
2020
pubmed:
14
2
2020
medline:
20
2
2021
Statut:
epublish
Résumé
In Senegal, chikungunya virus (CHIKV) is maintained in a sylvatic cycle and causes sporadic cases or small outbreaks in rural areas. However, little is known about the influence of the environment on its transmission. To address the question, 120 villages were randomly selected in the Kedougou region of southeastern Senegal. In each selected village, 10 persons by randomly selected household were sampled and tested for specific anti-CHIKV IgG antibodies by ELISA. We investigated the association of CHIKV seroprevalence with environmental variables using logistic regression analysis and the spatial correlation of village seroprevalence based on semivariogram analysis. Fifty-four percent (51%-57%) of individuals sampled during the survey tested positive for CHIKV-specific IgG. CHIKV seroprevalence was significantly higher in populations living close to forested areas (Normalized Difference Vegetation Index (NDVI), Odds Ratio (OR) = 1.90 (1.42-2.57)), and was negatively associated with population density (OR = 0.76 (0.69-0.84)). In contrast, in gold mining sites where population density was >400 people per km
Identifiants
pubmed: 32050663
pii: v12020196
doi: 10.3390/v12020196
pmc: PMC7077306
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : AI1069145.
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Nat Commun. 2018 Mar 13;9(1):1046
pubmed: 29535306
Dakar Med. 1983;28(3):497-500
pubmed: 6323109
Emerg Infect Dis. 2011 May;17(5):910-3
pubmed: 21529410
Baillieres Clin Rheumatol. 1995 Feb;9(1):145-50
pubmed: 7728877
World J Virol. 2012 Feb 12;1(1):11-22
pubmed: 24175207
J Virol. 2010 Jul;84(13):6497-504
pubmed: 20410280
Vector Borne Zoonotic Dis. 2012 Jun;12(6):435-47
pubmed: 22448724
J Med Entomol. 1996 Sep;33(5):760-5
pubmed: 8840681
Adv Parasitol. 2006;62:37-77
pubmed: 16647967
J Am Mosq Control Assoc. 1998 Mar;14(1):83-94
pubmed: 9599329
Am J Trop Med Hyg. 1999 Feb;60(2):281-6
pubmed: 10072152
Open Forum Infect Dis. 2017 Dec 02;5(1):ofx259
pubmed: 29354659
Semin Pediatr Infect Dis. 2006 Apr;17(2):99-104
pubmed: 16822471
J Virol. 2001 Nov;75(21):10118-31
pubmed: 11581380
Am J Trop Med Hyg. 2010 Mar;82(3):508-11
pubmed: 20207883
Curr Opin Rheumatol. 1996 Jan;8(1):85-9
pubmed: 8867545
PLoS Med. 2006 Jul;3(7):e263
pubmed: 16700631
J Travel Med. 2009 Jul-Aug;16(4):286-8
pubmed: 19674271
Bull Soc Med Afr Noire Lang Fr. 1969;14(4):722-8
pubmed: 5407134
Emerg Infect Dis. 2007 May;13(5):764-7
pubmed: 17553261
Parasit Vectors. 2010 Apr 08;3(1):35
pubmed: 20377873
Bull Soc Pathol Exot. 1993;86(1):21-8
pubmed: 8099299
Asian Pac J Trop Med. 2014 Dec;7(12):925-32
pubmed: 25479619
PLoS Negl Trop Dis. 2012;6(6):e1649
pubmed: 22720097
Antiviral Res. 2010 Feb;85(2):328-45
pubmed: 19857523
Science. 2013 Nov 15;342(6160):850-3
pubmed: 24233722
Am J Trop Med Hyg. 2005 Aug;73(2):445-9
pubmed: 16103619
Bull Soc Pathol Exot. 1999 May;92(2):79-82
pubmed: 10399593
J Hyg (Lond). 1956 Jun;54(2):177-91
pubmed: 13346078
Ann Intern Med. 1967 Jun;66(6):1129-43
pubmed: 5338939
Nature. 2016 Dec 21;540(7634):525
pubmed: 30905934
Bull Soc Med Afr Noire Lang Fr. 1967;12(3):490-6
pubmed: 5598039