The quail genome: insights into social behaviour, seasonal biology and infectious disease response.
Bird flu
Coturnix japonica
Genome
H5N1
Influenza
Photoperiod
Quail
Seasonality
Journal
BMC biology
ISSN: 1741-7007
Titre abrégé: BMC Biol
Pays: England
ID NLM: 101190720
Informations de publication
Date de publication:
12 02 2020
12 02 2020
Historique:
received:
07
06
2019
accepted:
24
01
2020
entrez:
14
2
2020
pubmed:
14
2
2020
medline:
30
9
2020
Statut:
epublish
Résumé
The Japanese quail (Coturnix japonica) is a popular domestic poultry species and an increasingly significant model species in avian developmental, behavioural and disease research. We have produced a high-quality quail genome sequence, spanning 0.93 Gb assigned to 33 chromosomes. In terms of contiguity, assembly statistics, gene content and chromosomal organisation, the quail genome shows high similarity to the chicken genome. We demonstrate the utility of this genome through three diverse applications. First, we identify selection signatures and candidate genes associated with social behaviour in the quail genome, an important agricultural and domestication trait. Second, we investigate the effects and interaction of photoperiod and temperature on the transcriptome of the quail medial basal hypothalamus, revealing key mechanisms of photoperiodism. Finally, we investigate the response of quail to H5N1 influenza infection. In quail lung, many critical immune genes and pathways were downregulated after H5N1 infection, and this may be key to the susceptibility of quail to H5N1. We have produced a high-quality genome of the quail which will facilitate further studies into diverse research questions using the quail as a model avian species.
Sections du résumé
BACKGROUND
The Japanese quail (Coturnix japonica) is a popular domestic poultry species and an increasingly significant model species in avian developmental, behavioural and disease research.
RESULTS
We have produced a high-quality quail genome sequence, spanning 0.93 Gb assigned to 33 chromosomes. In terms of contiguity, assembly statistics, gene content and chromosomal organisation, the quail genome shows high similarity to the chicken genome. We demonstrate the utility of this genome through three diverse applications. First, we identify selection signatures and candidate genes associated with social behaviour in the quail genome, an important agricultural and domestication trait. Second, we investigate the effects and interaction of photoperiod and temperature on the transcriptome of the quail medial basal hypothalamus, revealing key mechanisms of photoperiodism. Finally, we investigate the response of quail to H5N1 influenza infection. In quail lung, many critical immune genes and pathways were downregulated after H5N1 infection, and this may be key to the susceptibility of quail to H5N1.
CONCLUSIONS
We have produced a high-quality genome of the quail which will facilitate further studies into diverse research questions using the quail as a model avian species.
Identifiants
pubmed: 32050986
doi: 10.1186/s12915-020-0743-4
pii: 10.1186/s12915-020-0743-4
pmc: PMC7017630
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/20211550
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : HHSN272201400006C
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N015347/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : HHSN266200700005C
Pays : United States
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