Immunomodulatory Strategies in Herpes Simplex Virus Encephalitis.
encephalitis
herpes simplex virus
immune response
immunomodulatory drugs
Journal
Clinical microbiology reviews
ISSN: 1098-6618
Titre abrégé: Clin Microbiol Rev
Pays: United States
ID NLM: 8807282
Informations de publication
Date de publication:
18 03 2020
18 03 2020
Historique:
entrez:
14
2
2020
pubmed:
14
2
2020
medline:
30
4
2021
Statut:
epublish
Résumé
Herpes simplex virus 1 (HSV-1) can be responsible for life-threatening HSV encephalitis (HSE). The mortality rate of patients with HSE who do not receive antiviral treatment is 70%, with most survivors suffering from permanent neurological sequelae. The use of intravenous acyclovir together with improved diagnostic technologies such as PCR and magnetic resonance imaging has resulted in a reduction in the mortality rate to close to 20%. However, 70% of surviving patients still do not recover complete neurological functions. Thus, there is an urgent need to develop more effective treatments for a better clinical outcome. It is well recognized that cerebral damage resulting from HSE is caused by viral replication together with an overzealous inflammatory response. Both of these processes constitute potential targets for the development of innovative therapies against HSE. In this review, we discuss recent progress in therapy that may be used to ameliorate the outcome of patients with HSE, with a particular emphasis on immunomodulatory agents. Ideally, the administration of adjunctive immunomodulatory drugs should be initiated during the rise of the inflammatory response, and its duration should be limited in time to reduce undesired effects. This critical time frame should be optimized by the identification of reliable biomarkers of inflammation.
Identifiants
pubmed: 32051176
pii: 33/2/e00105-19
doi: 10.1128/CMR.00105-19
pmc: PMC7018500
pii:
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Antiviral Agents
0
Acyclovir
X4HES1O11F
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : 148361
Pays : Canada
Informations de copyright
Copyright © 2020 American Society for Microbiology.
Références
Mol Cell. 2014 Apr 24;54(2):289-96
pubmed: 24766893
Lancet. 1984 Sep 29;2(8405):707-11
pubmed: 6148470
J Clin Virol. 2014 Jan;59(1):67-70
pubmed: 24257111
Clin Infect Dis. 1994 May;18(5):744-9
pubmed: 8075263
Cell Host Microbe. 2016 Sep 14;20(3):329-341
pubmed: 27631700
Nat Rev Immunol. 2008 Jul;8(7):559-68
pubmed: 18575461
J Pediatr. 2010 Oct;157(4):623-9, 629.e1
pubmed: 20553844
J Pediatric Infect Dis Soc. 2014 Jun;3(2):e24-7
pubmed: 26625375
Scand J Infect Dis. 2014 Feb;46(2):152-4
pubmed: 24228826
Biochimie. 1998 Nov;80(11):899-904
pubmed: 9893949
Eur J Neurol. 2007 Jul;14(7):e18-9
pubmed: 17594308
J Neurol Neurosurg Psychiatry. 1996 Oct;61(4):339-45
pubmed: 8890768
Adv Virus Res. 2015;92:63-100
pubmed: 25701886
Neurobiol Dis. 2010 Jan;37(1):13-25
pubmed: 19664713
Clin Microbiol Infect. 2009 Jun;15(6):560-4
pubmed: 19392906
J Infect Dis. 2007 Mar 15;195(6):817-25
pubmed: 17299711
J Infect Dis. 2010 Nov 15;202(10):1492-9
pubmed: 20923374
Clin Infect Dis. 2007 Oct 1;45(7):875-80
pubmed: 17806053
J Neurol. 2015 Sep;262(9):2101-5
pubmed: 26092520
N Engl J Med. 1977 Aug 11;297(6):289-94
pubmed: 195208
Clin Infect Dis. 2004 May 15;38(10):1506-7
pubmed: 15156497
J Infect Dis. 1995 Apr;171(4):857-63
pubmed: 7706811
Clin Infect Dis. 1999 Jan;28(1):148-9
pubmed: 10028092
Virology. 2019 Mar;529:23-28
pubmed: 30648635
Biochem Pharmacol. 2010 Dec 15;80(12):1955-72
pubmed: 20620129
Neurol Res. 2016 Aug;38(8):733-9
pubmed: 27354147
J Neuroinflammation. 2007 Apr 30;4:11
pubmed: 17470292
JAMA. 1988 Feb 19;259(7):1051-3
pubmed: 3339802
Bone Marrow Transplant. 2012 Nov;47(11):1482-3
pubmed: 22426751
Genes Immun. 2015 Dec;16(8):552-66
pubmed: 26513235
Crit Care Med. 2012 Apr;40(4):1385-6
pubmed: 22425858
Behav Neurol. 2017;2017:5238402
pubmed: 29358844
J Neurovirol. 2008 Nov;14(6):503-13
pubmed: 18991139
J Neurooncol. 2011 Nov;105(2):415-21
pubmed: 21637964
Brain Dev. 1996 Mar-Apr;18(2):150-2
pubmed: 8733910
J Neurol. 2006 Feb;253(2):163-70
pubmed: 16222428
Eur J Paediatr Neurol. 2008 Mar;12(2):72-81
pubmed: 17870623
Neurology. 2015 Nov 17;85(20):1736-43
pubmed: 26491084
Antiviral Res. 2015 Nov;123:105-13
pubmed: 26374952
Neurology. 2015 Jun 9;84(23):2377-8
pubmed: 25957334
Am J Gastroenterol. 2010 Jan;105(1):240-1
pubmed: 20054331
J Infect Dis. 1990 Apr;161(4):711-5
pubmed: 2156946
Semin Pediatr Infect Dis. 2005 Jan;16(1):17-23
pubmed: 15685145
Clin Microbiol Infect. 2020 Mar;26(3):281-290
pubmed: 31760115
Antiviral Res. 2012 Dec;96(3):414-21
pubmed: 23043942
J Infect Dis. 1986 Apr;153(4):721-31
pubmed: 3005432
Springerplus. 2014 Sep 13;3:524
pubmed: 25279315
Crit Care. 2015 Sep 21;19:345
pubmed: 26387515
Cell. 2010 Mar 19;140(6):805-20
pubmed: 20303872
Neurotherapeutics. 2016 Jul;13(3):493-508
pubmed: 27106239
Antimicrob Agents Chemother. 2011 Oct;55(10):4728-34
pubmed: 21788472
J Neuroimmune Pharmacol. 2019 Jun;14(2):157-172
pubmed: 30456443
Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):231-8
pubmed: 21496407
J Neurol Sci. 1998 Apr 15;157(1):82-9
pubmed: 9600681
J Pediatr. 2013 Apr;162(4):850-856.e2
pubmed: 23164315
Hum Pathol. 1998 Mar;29(3):215-22
pubmed: 9496822
J Child Neurol. 2016 Mar;31(3):345-50
pubmed: 26184485
Antiviral Res. 1999 Nov;44(1):75-8
pubmed: 10588335
J Virol. 1975 Jan;15(1):36-40
pubmed: 163344
J Neurol. 2009 Apr;256(4):586-90
pubmed: 19367359
Science. 2006 Oct 13;314(5797):308-12
pubmed: 16973841
J Clin Immunol. 2018 Jan;38(1):129-143
pubmed: 29226301
Mult Scler Relat Disord. 2013 Oct;2(4):385-7
pubmed: 25877850
Anticancer Res. 2014 Aug;34(8):4411-4
pubmed: 25075078
Curr Opin Allergy Clin Immunol. 2007 Dec;7(6):495-505
pubmed: 17989525
Brain. 2001 Oct;124(Pt 10):2014-27
pubmed: 11571219
J Clin Microbiol. 2013 Jan;51(1):356-9
pubmed: 23100343
Neurology. 2003 Jul 22;61(2):241-3
pubmed: 12874408
PLoS One. 2012;7(4):e36216
pubmed: 22558388
Arch Neurol. 2006 Oct;63(10):1383-7
pubmed: 17030653
Clin Neurophysiol. 2015 Aug;126(8):1524-31
pubmed: 25476700
J Neurovirol. 2003 Feb;9(1):118-25
pubmed: 12587075
Pharmacol Rep. 2011;63(5):1203-9
pubmed: 22180363
J R Coll Physicians Lond. 1972 Oct;7(1):34-44
pubmed: 4342467
Ann Neurol. 1994 Dec;36(6):823-9
pubmed: 7998767
Neuroscience. 2001;108(1):119-27
pubmed: 11738136
Nat Immunol. 2018 Oct;19(10):1071-1082
pubmed: 30201994
Lancet. 1972 Mar 25;1(7752):695
pubmed: 4125204
Neurosci Lett. 1993 Jul 23;157(2):215-8
pubmed: 8233057
J Immunol. 2010 Jun 15;184(12):7010-21
pubmed: 20483728
PLoS One. 2014 Sep 05;9(9):e104169
pubmed: 25192177
Cytokine. 2009 May;46(2):187-93
pubmed: 19261488
N Engl J Med. 2010 Feb 4;362(5):402-15
pubmed: 20089954
Lancet Neurol. 2018 Sep;17(9):760-772
pubmed: 30049614
Arch Neurol. 1972 Aug;27(2):103-8
pubmed: 4557267
Arch Neurol. 1976 Jun;33(6):442-6
pubmed: 180935
Case Rep Oncol. 2014 Nov 21;7(3):774-9
pubmed: 25722668
Eur J Neurol. 2012 Oct;19(10):1278-91
pubmed: 22882231
Nat Immunol. 2010 May;11(5):373-84
pubmed: 20404851
J Neurol. 2003 Jul;250(7):867-8
pubmed: 12883931
J Biol Chem. 2007 Jul 13;282(28):20059-63
pubmed: 17502367
Viruses. 2010 Oct;2(10):2213-25
pubmed: 21994617
Mult Scler. 2012 Jun;18(6):909-11
pubmed: 22048950
N Engl J Med. 1986 Jan 16;314(3):144-9
pubmed: 3001520
Neurosci Lett. 1998 Mar 6;244(1):9-12
pubmed: 9578132
J Neuropathol Exp Neurol. 1999 Jan;58(1):61-77
pubmed: 10068315
J Virol. 2007 Feb;81(3):1451-60
pubmed: 17108044
J Pediatric Infect Dis Soc. 2015 Jun;4(2):e17-21
pubmed: 26185621
Mult Scler Relat Disord. 2018 Nov;26:68-70
pubmed: 30227312
J Virol. 2007 Aug;81(15):8157-64
pubmed: 17522198
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11416-21
pubmed: 15272082
Dev Med Child Neurol. 2017 Aug;59(8):806-814
pubmed: 28439892
Pediatr Neurol. 2007 Sep;37(3):229-32
pubmed: 17765816
PLoS Pathog. 2011 Jun;7(6):e1002071
pubmed: 21655109
Nature. 2008 Mar 13;452(7184):234-8
pubmed: 18305481
J Neurovirol. 2017 Apr;23(2):335-337
pubmed: 27787806
Clin Infect Dis. 2015 Sep 1;61(5):683-91
pubmed: 25956891
J Exp Med. 2011 Sep 26;208(10):2083-98
pubmed: 21911422
Ann Neurol. 2014 Feb;75(2):317-23
pubmed: 24318406
Crit Care Med. 2012 Apr;40(4):1304-8
pubmed: 22067626
Neurology. 2014 Nov 18;83(21):1888-97
pubmed: 25339207
Blood. 2004 Feb 15;103(4):1433-7
pubmed: 14563635
J Exp Med. 2012 Aug 27;209(9):1567-82
pubmed: 22851595
Neurol Res. 2010 Oct;32(8):801-9
pubmed: 20483026
Clin Infect Dis. 2013 Sep;57(6):849-52
pubmed: 23728144
Ann Neurol. 2014 Mar;75(3):411-28
pubmed: 24700511
Ann Neurol. 1979 Jan;5(1):2-5
pubmed: 426465
Lung Cancer. 2007 Aug;57(2):243-6
pubmed: 17368625
J Neurol Sci. 1965 Jul-Aug;2(4):328-43
pubmed: 4298554
Am J Pathol. 1986 Nov;125(2):332-8
pubmed: 3789090
J Immunol. 2005 Oct 1;175(7):4189-93
pubmed: 16177057
Cell Rep. 2018 Oct 2;25(1):118-129.e4
pubmed: 30282022
Acta Trop. 2010 Dec;116(3):206-11
pubmed: 20816658
Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1423-6
pubmed: 16029802
Haematologica. 2011 Jan;96(1):142-9
pubmed: 20851868
PLoS Pathog. 2019 Dec 23;15(12):e1008168
pubmed: 31869396
Antimicrob Agents Chemother. 2015;59(6):3084-9
pubmed: 25779579
J Clin Virol. 2016 Jul;80:87-92
pubmed: 27218417
J Neuroimmunol. 2006 Feb;171(1-2):171-6
pubmed: 16325272
J Leukoc Biol. 2004 Feb;75(2):163-89
pubmed: 14525967
Front Mol Neurosci. 2019 Apr 26;12:83
pubmed: 31080403
Cell. 2006 Feb 24;124(4):783-801
pubmed: 16497588
Epidemiol Infect. 2012 Feb;140(2):372-81
pubmed: 21470440
Cytokine Growth Factor Rev. 2014 Dec;25(6):641-8
pubmed: 25007740
J Clin Invest. 2011 Dec;121(12):4889-902
pubmed: 22105173
J Med Virol. 1993 Mar;39(3):179-86
pubmed: 8385702
J Immunol. 2008 Nov 1;181(9):6417-26
pubmed: 18941232
Epilepsia. 2008 Aug;49 Suppl 6:13-8
pubmed: 18754956
J Neurooncol. 2010 Oct;100(1):137-40
pubmed: 20148285
Clin Infect Dis. 2002 Aug 1;35(3):254-60
pubmed: 12115090
Clin Infect Dis. 2009 Sep 15;49(6):924-7
pubmed: 19681709
J Infect. 2012 Apr;64(4):347-73
pubmed: 22120595
Nat Rev Immunol. 2018 Apr;18(4):225-242
pubmed: 29151590
Eur J Obstet Gynecol Reprod Biol. 2011 Feb;154(2):231-2
pubmed: 21163567
Mult Scler Relat Disord. 2016 Nov;10:134-136
pubmed: 27919480
J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1544-9
pubmed: 16227548
J Infect Dis. 1996 Dec;174(6):1162-7
pubmed: 8940204
J Infect Dis. 1994 Sep;170(3):678-81
pubmed: 8077727
Antimicrob Agents Chemother. 2011 Feb;55(2):459-72
pubmed: 21078929
J Gen Virol. 2009 Jan;90(Pt 1):74-8
pubmed: 19088275
J Neurol. 2009 Aug;256(8):1243-51
pubmed: 19353228
Neuropathol Appl Neurobiol. 2000 Jun;26(3):285-94
pubmed: 10886686
J Infect Dis. 2016 May 15;213(10):1651-60
pubmed: 26712949
Clin Transplant. 2007 Sep-Oct;21(5):675-80
pubmed: 17845644
Pediatrics. 2001 Aug;108(2):230-8
pubmed: 11483782
Biochimie. 2007 Jun-Jul;89(6-7):878-83
pubmed: 17561326
J Infect. 2017 Jan;74(1):42-49
pubmed: 27717782
Clin Infect Dis. 2002 Apr 15;34(8):1154-7
pubmed: 11915008
Curr Infect Dis Rep. 2017 Mar;19(3):13
pubmed: 28251511
Virology. 1997 Nov 24;238(2):189-97
pubmed: 9400592
Mol Neurobiol. 2015 Dec;52(3):1547-1560
pubmed: 25367881
Ann Neurol. 2010 Jun;67(6):830-3
pubmed: 20517946
Nat Rev Immunol. 2011 Feb;11(2):143-54
pubmed: 21267015
Antiviral Res. 2013 Dec;100(3):649-53
pubmed: 24416771
Acta Neuropathol. 2017 Apr;133(4):613-627
pubmed: 27817117
Neurology. 2012 Nov 20;79(21):2125-32
pubmed: 23136265
Clin Infect Dis. 2000 Jan;30(1):185-7
pubmed: 10619751
J Virol. 2010 Nov;84(21):11350-8
pubmed: 20739519
J Virol. 2007 Dec;81(24):13315-24
pubmed: 17913820
J Allergy Clin Immunol. 2011 Sep;128(3):610-7.e1-4
pubmed: 21722947
J Neurosci. 2012 Aug 8;32(32):11082-94
pubmed: 22875940
Nat Genet. 2003 Mar;33(3):388-91
pubmed: 12590259
Neurology. 2014 Feb 4;82(5):443-51
pubmed: 24384647
BMC Infect Dis. 2012 Dec 18;12:356
pubmed: 23245564
J Neurol Sci. 1998 May 7;157(2):148-53
pubmed: 9619637
Nat Neurosci. 2005 Jun;8(6):752-8
pubmed: 15895084
Acta Neuropathol. 2018 Sep;136(3):461-482
pubmed: 30027450
Cytokine. 2016 Jan;77:227-37
pubmed: 26463515
MedGenMed. 2004 Nov 10;6(4):7
pubmed: 15775834
J Infect Dis. 1993 Nov;168(5):1248-52
pubmed: 8228358
Anticancer Res. 2013 Aug;33(8):3263-8
pubmed: 23898089
Mamm Genome. 2018 Aug;29(7-8):425-445
pubmed: 30167845
Mov Disord. 2014 Jan;29(1):117-22
pubmed: 24115338
Ann Neurol. 2012 Dec;72(6):902-11
pubmed: 23280840
Case Rep Neurol. 2013 Mar 21;5(1):52-5
pubmed: 23626565
Nature. 2012 Nov 29;491(7426):769-73
pubmed: 23103873
Brain Res. 2006 Dec 13;1125(1):155-62
pubmed: 17109833
Neurosci Lett. 2002 Jan 18;318(1):21-4
pubmed: 11786216
Clin Microbiol Infect. 2016 Nov;22(11):934-940
pubmed: 27497810
Am J Med. 1998 Oct;105(4):287-95
pubmed: 9809689
J Clin Microbiol. 2016 Sep;54(9):2251-61
pubmed: 27335149
Br J Pharmacol. 2013 Mar;168(5):1048-58
pubmed: 23072338
J Exp Med. 2003 Aug 4;198(3):513-20
pubmed: 12900525
Clin Infect Dis. 2003 May 15;36(10):1335-9
pubmed: 12746782
Immunity. 2010 Sep 24;33(3):400-11
pubmed: 20832341
J Exp Med. 2000 May 1;191(9):1459-66
pubmed: 10790421
Antimicrob Agents Chemother. 1987 Jul;31(7):1006-9
pubmed: 2821882
J Infect Dis. 2017 May 1;215(9):1430-1434
pubmed: 28368532
Science. 2013 Sep 20;341(6152):1390-4
pubmed: 23989956
Eur J Paediatr Neurol. 1997;1(1):41-5
pubmed: 10728192
Neurol Int. 2009 Nov 16;1(1):e9
pubmed: 21577367
Molecules. 2015 Jan 29;20(2):2229-71
pubmed: 25642836
Lancet. 1971 Feb 6;1(7693):290-1
pubmed: 4100031
Mikrobiyol Bul. 2007 Oct;41(4):613-9
pubmed: 18173083
Nat Commun. 2016 Nov 10;7:13348
pubmed: 27830700
J Exp Med. 2015 Aug 24;212(9):1371-9
pubmed: 26216125
Neuroimmunomodulation. 2015;22(1-2):20-32
pubmed: 25227506
Clin Infect Dis. 2008 Aug 1;47(3):303-27
pubmed: 18582201
J Infect Dis. 2007 Sep 15;196(6):853-60
pubmed: 17703415
J Neurol. 2000 Aug;247(8):636-42
pubmed: 11041333
J Clin Microbiol. 2018 Mar 26;56(4):
pubmed: 29436421
Neurol Neuroimmunol Neuroinflamm. 2019 Sep 5;6(6):
pubmed: 31488627
J Neurol Sci. 1982 May;54(2):209-26
pubmed: 6284882
J Neurovirol. 2016 Feb;22(1):33-7
pubmed: 26139017
J Clin Virol. 2014 Jun;60(2):112-8
pubmed: 24768322
Curr Top Microbiol Immunol. 2009;336:1-14
pubmed: 19688325
J Immunol. 1992 Oct 15;149(8):2736-41
pubmed: 1383325
J Infect Dis. 2008 Sep 1;198(5):664-72
pubmed: 18662130
J Neurovirol. 2000 Feb;6(1):25-32
pubmed: 10786994
Nat Neurosci. 2006 Dec;9(12):1512-9
pubmed: 17115040
Eur Neurol. 2003;50(4):225-9
pubmed: 14634267
J Virol. 2006 May;80(10):5059-64
pubmed: 16641297
Science. 2007 Sep 14;317(5844):1522-7
pubmed: 17872438
Schweiz Arch Neurol Psychiatr (1985). 1995;146(6):277-80
pubmed: 8867358
Neurology. 1999 Mar 23;52(5):1108-9
pubmed: 10102451
Lancet Neurol. 2019 Nov;18(11):1045-1057
pubmed: 31326280
Rev Med Virol. 2012 Mar;22(2):106-21
pubmed: 22020814
Br Med J. 1980 Nov 22;281(6252):1392
pubmed: 7437807