Increased and More Heterogeneous Gadoxetic Acid Uptake of the Liver Parenchyma after Hepatitis C Virus Eradication by Direct Antiviral Agent.
Aged
Antiviral Agents
/ therapeutic use
Female
Gadolinium DTPA
/ pharmacokinetics
Hepacivirus
/ drug effects
Hepatitis C, Chronic
/ diagnostic imaging
Hepatocytes
/ pathology
Humans
Liver
/ diagnostic imaging
Magnetic Resonance Imaging
Male
Middle Aged
Muscle, Skeletal
/ diagnostic imaging
Retrospective Studies
Sustained Virologic Response
direct-antiviral agent (DAA)
gadoxetic acid
hepatitis C virus (HCV)
sustained virological response (SVR)
Journal
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
ISSN: 1880-2206
Titre abrégé: Magn Reson Med Sci
Pays: Japan
ID NLM: 101153368
Informations de publication
Date de publication:
01 Dec 2020
01 Dec 2020
Historique:
pubmed:
14
2
2020
medline:
17
4
2021
entrez:
14
2
2020
Statut:
ppublish
Résumé
We evaluated the changes of gadoxetic acid uptake of the liver parenchyma after hepatitis C virus (HCV) eradication by direct-antiviral agent (DAA) therapy. The increase rate of the liver-to-muscle signal intensity ratio, the skewness and the kurtosis were calculated in the hepatobiliary phase. After sustained virological response, gadoxetic acid uptake of the liver parenchyma increased, but became heterogeneous. Our study proved that HCV eradication by DAA therapy could significantly affect gadoxetic acid uptake.
Identifiants
pubmed: 32051362
doi: 10.2463/mrms.tn.2019-0183
pmc: PMC7809143
doi:
Substances chimiques
Antiviral Agents
0
gadolinium ethoxybenzyl DTPA
0
Gadolinium DTPA
K2I13DR72L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
389-393Références
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