NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Biocatalysis
Cryoelectron Microscopy
Humans
Models, Molecular
NEDD8 Protein
/ chemistry
NF-KappaB Inhibitor alpha
/ chemistry
Phosphorylation
Protein Conformation
Substrate Specificity
Ubiquitin
/ metabolism
Ubiquitin-Conjugating Enzymes
/ chemistry
Ubiquitin-Protein Ligases
/ chemistry
Ubiquitination
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
16
08
2019
accepted:
09
01
2020
pubmed:
14
2
2020
medline:
30
5
2020
entrez:
14
2
2020
Statut:
ppublish
Résumé
Eukaryotic cell biology depends on cullin-RING E3 ligase (CRL)-catalysed protein ubiquitylation
Identifiants
pubmed: 32051583
doi: 10.1038/s41586-020-2000-y
pii: 10.1038/s41586-020-2000-y
pmc: PMC7050210
mid: NIHMS1548771
doi:
Substances chimiques
NEDD8 Protein
0
NEDD8 protein, human
0
Ubiquitin
0
NF-KappaB Inhibitor alpha
139874-52-5
UBE2D1 protein, human
EC 2.3.2.23
Ubiquitin-Conjugating Enzymes
EC 2.3.2.23
CULL-RING ligase, human
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
461-466Subventions
Organisme : European Research Council
ID : 789016
Pays : International
Organisme : NIGMS NIH HHS
ID : R15 GM117555
Pays : United States
Commentaires et corrections
Type : CommentIn
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