TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise.
AMP-Activated Protein Kinases
/ metabolism
Animals
Autophagy
Beclin-1
/ metabolism
Enzyme Activation
Exercise
Glucose
/ metabolism
Humans
Male
Mice
Models, Animal
Muscle, Skeletal
/ enzymology
Phosphatidylinositol 3-Kinase
/ metabolism
Physical Conditioning, Animal
/ physiology
Toll-Like Receptor 9
/ deficiency
Tumor Suppressor Proteins
/ metabolism
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
07
09
2018
accepted:
12
12
2019
pubmed:
14
2
2020
medline:
4
4
2020
entrez:
14
2
2020
Statut:
ppublish
Résumé
The activation of adenosine monophosphate-activated protein kinase (AMPK) in skeletal muscle coordinates systemic metabolic responses to exercise
Identifiants
pubmed: 32051584
doi: 10.1038/s41586-020-1992-7
pii: 10.1038/s41586-020-1992-7
pmc: PMC7047589
mid: NIHMS1546557
doi:
Substances chimiques
Beclin-1
0
Becn1 protein, mouse
0
Tlr9 protein, mouse
0
Toll-Like Receptor 9
0
Tumor Suppressor Proteins
0
UVRAG protein, mouse
0
Phosphatidylinositol 3-Kinase
EC 2.7.1.137
AMP-Activated Protein Kinases
EC 2.7.11.31
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
605-609Subventions
Organisme : NCI NIH HHS
ID : R01 CA109618
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109725
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142784
Pays : United States
Commentaires et corrections
Type : CommentIn
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