Determination of acrolein-associated T
Journal
Applied magnetic resonance
ISSN: 0937-9347
Titre abrégé: Appl Magn Reson
Pays: Austria
ID NLM: 9204100
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
entrez:
14
2
2020
pubmed:
14
2
2020
medline:
14
2
2020
Statut:
ppublish
Résumé
An estimated 3.3 million people are living with a traumatic brain injury (TBI)-associated morbidity. Currently, only invasive and sacrificial methods exist to study neurochemical alterations following TBI. Nuclear magnetic resonance methods-magnetic resonance imaging (MRI) and spectroscopy (MRS)-are powerful tools which may be used non-invasively to diagnose a range of medical issues. These methods can be utilized to explore brain functionality, connectivity, and biochemistry. Unfortunately, many of the commonly studied brain metabolites (e.g., N-acetyl-aspartate, choline, creatine) remain relatively stable following mild to moderate TBI and may not be suitable for longitudinal assessment of injury severity and location. Therefore, a critical need exists to investigate alternative biomarkers of TBI, such as acrolein. Acrolein is a byproduct of lipid peroxidation and accumulates following damage to neuronal tissue. Acrolein has been shown to increase in post-mortem rat brain tissue following TBI. However, no methods exist to noninvasively quantify acrolein
Identifiants
pubmed: 32051668
doi: 10.1007/s00723-019-01148-2
pmc: PMC7015257
mid: NIHMS1054827
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1291-1303Subventions
Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073636
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS090244
Pays : United States
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
Brain Inj. 2017;31(9):1195-1203
pubmed: 28981341
J Neurosurg. 2016 Mar;124(3):675-86
pubmed: 26295915
Free Radic Res. 2015;49(7):888-95
pubmed: 25879847
Dev Neuropsychol. 2014;39(6):459-73
pubmed: 25144258
Cell Mol Gastroenterol Hepatol. 2016 May 27;2(5):685-700
pubmed: 28119953
J Magn Reson. 1999 Sep;140(1):250-8
pubmed: 10479569
Magn Reson Med. 1993 Dec;30(6):672-9
pubmed: 8139448
Mol Nutr Food Res. 2011 Sep;55(9):1320-31
pubmed: 21823221
J Med Phys. 2010 Jul;35(3):154-63
pubmed: 20927223
Top Magn Reson Imaging. 2010 Apr;21(2):115-28
pubmed: 21613876
Front Neurol. 2018 Jun 15;9:420
pubmed: 29963001
NMR Biomed. 2019 Mar;32(3):e4058
pubmed: 30663818
Free Radic Biol Med. 2008 Aug 15;45(4):443-52
pubmed: 18501200
Sleep. 2008 Jun;31(6):777-94
pubmed: 18548822
J Neurochem. 2008 Nov;107(3):712-21
pubmed: 18710419
Neurochem Res. 2005 Mar;30(3):291-5
pubmed: 16018572
Front Neurol. 2017 Sep 12;8:426
pubmed: 28955291
Neurosci Biobehav Rev. 2016 Sep;68:460-473
pubmed: 27181909
Anal Biochem. 2017 Jul 15;529:30-39
pubmed: 27773654
J Comput Assist Tomogr. 2016 Jan-Feb;40(1):1-13
pubmed: 26484954
Nat Rev Neurol. 2017 Mar;13(3):171-191
pubmed: 28186177
Chem Commun (Camb). 2012 Jan 21;48(6):811-3
pubmed: 22143456
J Neurotrauma. 2009 Oct;26(10):1635-43
pubmed: 19355814
J Bioenerg Biomembr. 2016 Apr;48(2):169-74
pubmed: 25595872
AJR Am J Roentgenol. 1991 Nov;157(5):1073-8
pubmed: 1927795
Eur J Cancer. 2013 Feb;49(3):658-67
pubmed: 23036849
Rev Environ Contam Toxicol. 1995;144:95-146
pubmed: 8599034
Methods Mol Biol. 2011;711:203-26
pubmed: 21279603
Magn Reson Imaging. 2004 Sep;22(7):1017-24
pubmed: 15288143
Brain. 2010 Nov;133(11):3232-42
pubmed: 20736189
Free Radic Biol Med. 2006 Jul 1;41(1):77-85
pubmed: 16781455
Magn Reson Med. 2011 Jan;65(1):1-12
pubmed: 20878762
MMWR Surveill Summ. 2017 Mar 17;66(9):1-16
pubmed: 28301451