The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer.
colorectal cancer
polymorphism
risk factors
rs 1045642
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
11
2016
accepted:
29
06
2017
entrez:
14
2
2020
pubmed:
14
2
2020
medline:
14
2
2020
Statut:
epublish
Résumé
Colorectal cancer (CRC) is one of the most frequently diagnosed tumors in Western countries. CRC is a heterogeneous group of tumors with regards to its molecular pathogenesis and genetic factors. Both genetic variations and anthropometric factors may affect morbidity in CRC patients. The aim of this study was to assess the impact of multidrug resistance 1/ATP-binding cassette sub-family B member 1 gene (MDR1/ABCB1) polymorphism rs1045642 and general anthropometric factors on the CRC risk. The study included 250 patients who underwent colonoscopy and polypectomy between 2006 and 2013 in a single endoscopy unit in Warsaw, Poland. The CRC was diagnosed in 50 individuals, and 200 patients were included in the control group. Cases and controls were matched for mean age and sex ( The MDR1/ABCB1 gene polymorphism rs 1045642 may be involved in the pathogenesis of CRC and this relationship may be sex-specific for males. However, further population studies are necessary to assess this relationship.
Identifiants
pubmed: 32051713
doi: 10.5114/aoms.2017.70329
pii: 30683
pmc: PMC6963158
doi:
Types de publication
Journal Article
Langues
eng
Pagination
112-117Informations de copyright
Copyright: © 2017 Termedia & Banach.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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