Use of modified Custodiol-N as perfusion solution in ex vivo lung perfusion.
Custodiol-N
Marginal donor lungs
ex-vivo lung perfusion
lung transplantation
organ preservation
Journal
American journal of translational research
ISSN: 1943-8141
Titre abrégé: Am J Transl Res
Pays: United States
ID NLM: 101493030
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
05
2019
accepted:
26
07
2019
entrez:
14
2
2020
pubmed:
14
2
2020
medline:
14
2
2020
Statut:
epublish
Résumé
Ex vivo Lung Perfusion (EVLP) is a promising tool to increase the donor pool for lung transplantation. Custodiol-N solution was originally designed for organ preservation during cold static preservation (CSP) and was successfully used for machine perfusion in kidneys. It was the aim of this study to compare the lung functional outcomes after 4 hours of EVLP using modified Custodiol-N or STEEN Solution In a porcine DCD model, lungs were perfused either with STEEN Solution Lungs that underwent EVLP with modified Custodiol-N showed significantly higher oxygen capacity (ΔpO In a porcine DCD model of 9 hours CSP followed by four hours of EVLP the use of modified Custodiol-N as perfusion solution was feasible and associated with higher oxygen capacity than STEEN Solution
Types de publication
Journal Article
Langues
eng
Pagination
153-161Informations de copyright
AJTR Copyright © 2020.
Déclaration de conflit d'intérêts
None.
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