The Acute and Early Effects of Whole-Brain Irradiation on Glial Activation, Brain Metabolism, and Behavior: a Positron Emission Tomography Study.
Behavior
Brain imaging
Brain irradiation
Brain metabolism
Microglia activation
Neuroinflammation
PET imaging
Journal
Molecular imaging and biology
ISSN: 1860-2002
Titre abrégé: Mol Imaging Biol
Pays: United States
ID NLM: 101125610
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
pubmed:
14
2
2020
medline:
8
7
2021
entrez:
14
2
2020
Statut:
ppublish
Résumé
Radiotherapy is a frequently applied treatment modality for brain tumors. Concomitant irradiation of normal brain tissue can induce various physiological responses. The aim of this study was to investigate whether acute and early-delayed effects of brain irradiation on glial activation and brain metabolism can be detected with positron emission tomography (PET) and whether these effects are correlated with behavioral changes. Rats underwent 0-, 10-, or 25-Gy whole-brain irradiation. At 3 and 31 days post irradiation, 1-(2-chlorophenyl)-N-[ Twenty-five-gray-irradiated rats showed higher [ Non-invasive PET imaging indicated that brain irradiation induces neuroinflammation and a metabolic flare, without causing acute or early-delayed behavioral changes.
Identifiants
pubmed: 32052277
doi: 10.1007/s11307-020-01483-y
pii: 10.1007/s11307-020-01483-y
pmc: PMC7343765
doi:
Substances chimiques
Carbon Radioisotopes
0
Carbon-11
0
Isoquinolines
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
PK 11195
YNF83VN1RL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1012-1020Références
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