MEX3A regulates Lgr5
LGR5+ intestinal stem cells
PPARγ pathway
RNA-binding protein MEX3A
intestinal homeostasis
mouse model
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
03 04 2020
03 04 2020
Historique:
received:
24
07
2019
revised:
15
01
2020
accepted:
20
01
2020
pubmed:
14
2
2020
medline:
28
4
2021
entrez:
14
2
2020
Statut:
ppublish
Résumé
Intestinal stem cells (ISCs) fuel the lifelong self-renewal of the intestinal tract and are paramount for epithelial repair. In this context, the Wnt pathway component LGR5 is the most consensual ISC marker to date. Still, the effort to better understand ISC identity and regulation remains a challenge. We have generated a Mex3a knockout mouse model and show that this RNA-binding protein is crucial for the maintenance of the Lgr5
Identifiants
pubmed: 32052574
doi: 10.15252/embr.201948938
pmc: PMC7132344
doi:
Substances chimiques
Lgr5 protein, mouse
0
Receptors, G-Protein-Coupled
0
Banques de données
GEO
['GSE141191']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e48938Subventions
Organisme : MEC|Fundação para a Ciência e a Tecnologia (FCT)
ID : SFRH/BPD/109794/2015
Pays : International
Organisme : MEC|Fundação para a Ciência e a Tecnologia (FCT)
ID : POCI-01-0145-FEDER-007274
Pays : International
Organisme : MEC|Fundação para a Ciência e a Tecnologia (FCT)
ID : CEECIND/03235/2017
Pays : International
Organisme : MEC|Fundação para a Ciência e a Tecnologia (FCT)
ID : POCI-01-0145-FEDER-031538
Pays : International
Organisme : Norte Portugal Regional Programme (N2020)
ID : NORTE-01-0145-FEDER-000029
Pays : International
Organisme : INFRAFRONTIER-I3 project
Pays : International
Informations de copyright
© 2020 The Authors. Published under the terms of the CC BY 4.0 license.
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