Expression of nicotinamide adenine dinucleotide phosphate oxidase in chronic rhinosinusitis with nasal polyps.
Adult
Aged
Aldehydes
/ metabolism
Chronic Disease
Eosinophils
/ metabolism
Female
Humans
Male
Middle Aged
NADPH Oxidases
/ metabolism
Nasal Mucosa
/ metabolism
Nasal Polyps
/ metabolism
Neutrophils
/ metabolism
Oxidative Stress
Phosphoproteins
/ metabolism
Rhinitis
/ metabolism
Sinusitis
/ metabolism
4-HNE
NADPH oxidase
Western blot
chronic rhinosinusitis
gp91phox
p22phox
p47phox
p67phox
real-time PCR
Journal
International forum of allergy & rhinology
ISSN: 2042-6984
Titre abrégé: Int Forum Allergy Rhinol
Pays: United States
ID NLM: 101550261
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
07
06
2019
revised:
30
11
2019
accepted:
03
01
2020
pubmed:
14
2
2020
medline:
29
7
2021
entrez:
14
2
2020
Statut:
ppublish
Résumé
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase produces reactive oxygen species (ROS) involved in oxidative stress and signal transduction. Recent studies have suggested that NADPH oxidase is associated with the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). The aim of this study was to detect the expression of NADPH oxidase subunits and 4-hydroxynonenal (4-HNE) in nasal polyp tissue and normal nasal mucosa, in order to explore the possible role played by NADPH oxidase in the pathogenesis of CRSwNP. Thirteen patients with CRSwNP and 9 normal control subjects were selected to participate in this study, in which we evaluated the expression of different NADPH oxidase subunits (gp91 Western blot and real-time PCR results showed that p67 The levels of p67
Sections du résumé
BACKGROUND
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase produces reactive oxygen species (ROS) involved in oxidative stress and signal transduction. Recent studies have suggested that NADPH oxidase is associated with the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). The aim of this study was to detect the expression of NADPH oxidase subunits and 4-hydroxynonenal (4-HNE) in nasal polyp tissue and normal nasal mucosa, in order to explore the possible role played by NADPH oxidase in the pathogenesis of CRSwNP.
METHODS
Thirteen patients with CRSwNP and 9 normal control subjects were selected to participate in this study, in which we evaluated the expression of different NADPH oxidase subunits (gp91
RESULTS
Western blot and real-time PCR results showed that p67
CONCLUSION
The levels of p67
Substances chimiques
Aldehydes
0
Phosphoproteins
0
neutrophil cytosol factor 67K
0
NADPH Oxidases
EC 1.6.3.-
4-hydroxy-2-nonenal
K1CVM13F96
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
646-655Informations de copyright
© 2020 ARS-AAOA, LLC.
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