Shaping Pancreatic β-Cell Differentiation and Functioning: The Influence of Mechanotransduction.
YAP/TAZ
actin
diabetes
integrin
islet of Langerhans
mechanotransduction
nanotopography
stem cells
β-cells
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
11 02 2020
11 02 2020
Historique:
received:
23
12
2019
revised:
29
01
2020
accepted:
07
02
2020
entrez:
15
2
2020
pubmed:
15
2
2020
medline:
27
2
2021
Statut:
epublish
Résumé
Embryonic and pluripotent stem cells hold great promise in generating β-cells for both replacing medicine and novel therapeutic discoveries in diabetes mellitus. However, their differentiation in vitro is still inefficient, and functional studies reveal that most of these β-like cells still fail to fully mirror the adult β-cell physiology. For their proper growth and functioning, β-cells require a very specific environment, the islet niche, which provides a myriad of chemical and physical signals. While the nature and effects of chemical stimuli have been widely characterized, less is known about the mechanical signals
Identifiants
pubmed: 32053947
pii: cells9020413
doi: 10.3390/cells9020413
pmc: PMC7072458
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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