Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype.


Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
05 2021
Historique:
received: 24 07 2019
accepted: 03 02 2020
revised: 04 01 2020
pubmed: 15 2 2020
medline: 12 6 2021
entrez: 15 2 2020
Statut: ppublish

Résumé

Germline mutations in PTEN account for ~10% of cases of autism spectrum disorder (ASD) with coincident macrocephaly. To explore the importance of nuclear PTEN in the development of ASD and macrocephaly, we previously generated a mouse model with predominantly cytoplasmic localization of Pten (Pten

Identifiants

pubmed: 32055008
doi: 10.1038/s41380-020-0681-0
pii: 10.1038/s41380-020-0681-0
pmc: PMC8159731
doi:

Substances chimiques

PTEN Phosphohydrolase EC 3.1.3.67
Pten protein, mouse EC 3.1.3.67

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1458-1471

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS096148
Pays : United States

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Auteurs

Nicholas Sarn (N)

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of Genetics and Genome Sciences, Cleveland, OH, USA.

Ritika Jaini (R)

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Germline High Risk Cancer Focus Group, Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 44195, USA.

Stetson Thacker (S)

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 44195, USA.

Hyunpil Lee (H)

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Ranjan Dutta (R)

Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 44195, USA.
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Charis Eng (C)

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. engc@ccf.org.
Department of Genetics and Genome Sciences, Cleveland, OH, USA. engc@ccf.org.
Germline High Risk Cancer Focus Group, Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. engc@ccf.org.
Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 44195, USA. engc@ccf.org.

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