Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
24
07
2019
accepted:
03
02
2020
revised:
04
01
2020
pubmed:
15
2
2020
medline:
12
6
2021
entrez:
15
2
2020
Statut:
ppublish
Résumé
Germline mutations in PTEN account for ~10% of cases of autism spectrum disorder (ASD) with coincident macrocephaly. To explore the importance of nuclear PTEN in the development of ASD and macrocephaly, we previously generated a mouse model with predominantly cytoplasmic localization of Pten (Pten
Identifiants
pubmed: 32055008
doi: 10.1038/s41380-020-0681-0
pii: 10.1038/s41380-020-0681-0
pmc: PMC8159731
doi:
Substances chimiques
PTEN Phosphohydrolase
EC 3.1.3.67
Pten protein, mouse
EC 3.1.3.67
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1458-1471Subventions
Organisme : NINDS NIH HHS
ID : R01 NS096148
Pays : United States
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