Role of omega-3 fatty acids in the prevention of delirium in mechanically ventilated patients.
Delirium
inflammation
intensive care unit
mechanical ventilation
omega-3 fatty acids
Journal
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
ISSN: 1735-1995
Titre abrégé: J Res Med Sci
Pays: India
ID NLM: 101235599
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
08
2018
revised:
28
04
2019
accepted:
11
11
2019
entrez:
15
2
2020
pubmed:
15
2
2020
medline:
15
2
2020
Statut:
epublish
Résumé
Inflammation is an important mechanism in the pathogenesis of delirium. Since delirium might reduce by anti-inflammatory effects of omega-3 fatty acids. Based on this respect, a study was conducted to indicate the effect of omega-3 fatty acids in the prevention of delirium in mechanically ventilated patients. This study is a randomized, double-blind, placebo-controlled clinical trial. One hundred and sixty-eight mechanically ventilated patients were selected in the investigation. Patients were randomly allocated to receive either 2 g of omega-3 syrup or placebo once a day. Twice daily delirium was assessed due to Confusion Assessment Method and the Richmond Agitation-Sedation Scale. The number of days with delirium during the first 10 days of admission was the primary outcome. Secondary outcomes had been included duration of mechanical ventilation, length of intensive care unit (ICU) stay, and mortality. Patient-days with delirium ( Omega-3 fatty acids can reduce the risk of delirium in mechanically ventilated patients.
Sections du résumé
BACKGROUND
BACKGROUND
Inflammation is an important mechanism in the pathogenesis of delirium. Since delirium might reduce by anti-inflammatory effects of omega-3 fatty acids. Based on this respect, a study was conducted to indicate the effect of omega-3 fatty acids in the prevention of delirium in mechanically ventilated patients.
MATERIALS AND METHODS
METHODS
This study is a randomized, double-blind, placebo-controlled clinical trial. One hundred and sixty-eight mechanically ventilated patients were selected in the investigation. Patients were randomly allocated to receive either 2 g of omega-3 syrup or placebo once a day. Twice daily delirium was assessed due to Confusion Assessment Method and the Richmond Agitation-Sedation Scale. The number of days with delirium during the first 10 days of admission was the primary outcome. Secondary outcomes had been included duration of mechanical ventilation, length of intensive care unit (ICU) stay, and mortality.
RESULTS
RESULTS
Patient-days with delirium (
CONCLUSION
CONCLUSIONS
Omega-3 fatty acids can reduce the risk of delirium in mechanically ventilated patients.
Identifiants
pubmed: 32055250
doi: 10.4103/jrms.JRMS_567_18
pii: JRMS-25-10
pmc: PMC7003546
doi:
Types de publication
Journal Article
Langues
eng
Pagination
10Informations de copyright
Copyright: © 2020 Journal of Research in Medical Sciences.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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