Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function.
DNA nanotechnology
DNA tetrahedron nanoparticle
kidney dysfunction
positron emission tomography (PET) imaging
renal clearance
Journal
Nano research
ISSN: 1998-0124
Titre abrégé: Nano Res
Pays: China
ID NLM: 101518856
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
entrez:
15
2
2020
pubmed:
15
2
2020
medline:
15
2
2020
Statut:
ppublish
Résumé
DNA tetrahedron nanostructure (DTN) is one of the simplest DNA nanostructures and has been successfully applied for biosensing, imaging, and treatment of cancer. To facilitate its biomedical applications and potential clinical translation, fundamental understanding of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearance of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide insight for future optimization of DNA nanostructures for biomedical applications.
Identifiants
pubmed: 32055285
doi: 10.1007/s12274-019-2271-5
pmc: PMC7017644
mid: NIHMS1024744
doi:
Types de publication
Journal Article
Langues
eng
Pagination
637-642Subventions
Organisme : NCI NIH HHS
ID : P30 CA014520
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009206
Pays : United States
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