Chemical biology tools for probing transcytosis at the blood-brain barrier.
Journal
Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951
Informations de publication
Date de publication:
14 Dec 2019
14 Dec 2019
Historique:
received:
12
08
2019
accepted:
07
10
2019
entrez:
15
2
2020
pubmed:
15
2
2020
medline:
15
2
2020
Statut:
epublish
Résumé
Absorptive- and receptor-mediated transcytosis (AMT/RMT) are widely studied strategies to deliver therapeutics across the blood-brain barrier (BBB). However, an improved understanding of the mechanism surrounding trafficking is required that could promote delivery. Accordingly, we designed a flexible platform that merged AMT and RMT motifs on a single scaffold to probe various parameters (ligand, affinity, valency, position) in a screening campaign. During this process we adapted an
Identifiants
pubmed: 32055384
doi: 10.1039/c9sc04024b
pii: c9sc04024b
pmc: PMC7006505
doi:
Types de publication
Journal Article
Langues
eng
Pagination
10772-10778Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
This journal is © The Royal Society of Chemistry 2019.
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