Prospects for Therapies in Osteoarthritis.
Cartilage
DMOAD
Inflammation
Nociceptive pain
Osteoarthritis
Synovitis
Journal
Calcified tissue international
ISSN: 1432-0827
Titre abrégé: Calcif Tissue Int
Pays: United States
ID NLM: 7905481
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
14
11
2019
accepted:
06
02
2020
pubmed:
15
2
2020
medline:
16
10
2021
entrez:
15
2
2020
Statut:
ppublish
Résumé
Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients who can use them. New pharmacological therapies for managing OA are required and a number have been developed targeting different tissues in OA: bone and cartilage, synovium and nerves. However, there has been overall limited success. Disease-modifying osteoarthritis drugs (DMOADs) are a putative class of therapies aimed at improving OA structural pathologies and consequent symptoms. Recent DMOAD studies have demonstrated some promising therapies but also provided new considerations for future trials.
Identifiants
pubmed: 32055890
doi: 10.1007/s00223-020-00672-9
pii: 10.1007/s00223-020-00672-9
pmc: PMC8403110
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
339-350Subventions
Organisme : Versus Arthritis
ID : 20083
Pays : United Kingdom
Informations de copyright
© 2020. The Author(s).
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