A genome-wide association study on medulloblastoma.

Biomarkers, Tumor / genetics Case-Control Studies Cerebellar Neoplasms / genetics Cohort Studies Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Medulloblastoma / genetics Polymorphism, Single Nucleotide Prognosis
Adolescents and young adults (AYA) CNS cancers Epidemiology Genetics of risk, outcome, and prevention Pediatric cancers

Journal

Journal of neuro-oncology
ISSN: 1573-7373
Titre abrégé: J Neurooncol
Pays: United States
ID NLM: 8309335

Informations de publication

Date de publication:
Apr 2020
Historique:
received: 12 12 2019
accepted: 03 02 2020
pubmed: 15 2 2020
medline: 3 2 2021
entrez: 15 2 2020
Statut: ppublish

Résumé

Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS) including 244 medulloblastoma cases and 247 control subjects from Sweden and Denmark. Genotyping was performed using Illumina BeadChips, and untyped variants were imputed using IMPUTE2. Fifty-nine variants in 11 loci were associated with increased medulloblastoma risk (p < 1 × 10 The results of this study, including a novel potential medulloblastoma risk loci at 18p11.23, are suggestive but need further validation in independent cohorts.

Identifiants

DOI: 10.1007/s11060-020-03424-9 PMID: 32056145 PMC: PMC7136185
pubmed: 32056145
doi: 10.1007/s11060-020-03424-9
pii: 10.1007/s11060-020-03424-9
pmc: PMC7136185
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

309-315

Subventions

Organisme : NCI NIH HHS
ID : P01 CA196569
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES007033
Pays : United States
Organisme : NIH HHS
ID : R03CA106011
Pays : United States
Organisme : NIH HHS
ID : P30ES007033
Pays : United States
Organisme : NIH HHS
ID : R01CA116724
Pays : United States

Investigateurs

Michaela Prochazka (M)
Maral Adel Fahmideh (M)
Birgitta Lannering (B)
Lisbeth S Schmidt (LS)
Christoffer Johansen (C)
Astrid Sehested (A)
Claudia Kuehni (C)
Michael Grotzer (M)
Tore Tynes (T)
Tone Eggen (T)
Lars Klæboe (L)

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Auteurs

Anna M Dahlin (AM)

Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
ORCID: 0000-0002-6754-2571

Carl Wibom (C)

Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.

Ulrika Andersson (U)

Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.

Jonas Bybjerg-Grauholm (J)

Danish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.

Isabelle Deltour (I)

Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.
Unit of Statistics, Bioinformatics and Registry, Danish Cancer Society Research Center, Copenhagen, Denmark.

David M Hougaard (DM)

Danish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.

Michael E Scheurer (ME)

Department of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.

Ching C Lau (CC)

Department of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.

Roberta McKean-Cowdin (R)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Rebekah J Kennedy (RJ)

Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Long T Hung (LT)

Department of Pediatrics, Section of Hematology-Oncology, Children's Hospital Los Angeles and The Saban Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.

Janis Yee (J)

Department of Pediatrics, Section of Hematology-Oncology, Children's Hospital Los Angeles and The Saban Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.

Ashley S Margol (AS)

Department of Pediatrics, Section of Hematology-Oncology, Children's Hospital Los Angeles and The Saban Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.

Jessica Barrington-Trimis (J)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

W James Gauderman (WJ)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Maria Feychting (M)

Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Joachim Schüz (J)

Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.

Martin Röösli (M)

Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Kristina Kjaerheim (K)

The Cancer Registry of Norway, Oslo, Norway.

Danuta Januszkiewicz-Lewandowska (D)

Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Department of Pediatric Oncology, Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, Poland.

Marta Fichna (M)

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Jerzy Nowak (J)

Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.

Susan Searles Nielsen (S)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Neurology, School of Medicine, University of Washington, Seattle, WA, USA.

Shahab Asgharzadeh (S)

Department of Pediatrics, Section of Hematology-Oncology, Children's Hospital Los Angeles and The Saban Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Department of Pathology, Saban Research Institute at Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Lisa Mirabello (L)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Ulf Hjalmars (U)

Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.

Beatrice Melin (B)

Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden. beatrice.melin@umu.se.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › A genome-wide association study on medulloblastoma.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › A genome-wide association study on medulloblastoma.
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Tumeurs sous-tentorielles › Tumeurs du cervelet › A genome-wide association study on medulloblastoma.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › A genome-wide association study on medulloblastoma.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › A genome-wide association study on medulloblastoma.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › A genome-wide association study on medulloblastoma.
questionsmedicales.fr › Phénomènes génétiques › Génotype › A genome-wide association study on medulloblastoma.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A genome-wide association study on medulloblastoma.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Médulloblastome › A genome-wide association study on medulloblastoma.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › A genome-wide association study on medulloblastoma.
questionsmedicales.fr › Diagnostic › Pronostic › A genome-wide association study on medulloblastoma.