Investigating the effects of ebselen, a potential new lithium mimetic, on glutamate transmission.
Animals
Azoles
/ pharmacology
Brain
/ diagnostic imaging
Glutamic Acid
/ metabolism
Isoindoles
Organoselenium Compounds
/ pharmacology
Positron-Emission Tomography
Protein Binding
Psychotropic Drugs
/ pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Metabotropic Glutamate 5
/ metabolism
Synaptic Transmission
Journal
Synapse (New York, N.Y.)
ISSN: 1098-2396
Titre abrégé: Synapse
Pays: United States
ID NLM: 8806914
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
31
12
2019
revised:
11
02
2020
accepted:
11
02
2020
pubmed:
15
2
2020
medline:
10
8
2021
entrez:
15
2
2020
Statut:
ppublish
Résumé
Ebselen, a potential new lithium-like drug, treatment reduced brain glutamate, as measured by PET imaging using the mGluR5 radioligand [
Substances chimiques
Azoles
0
Isoindoles
0
Organoselenium Compounds
0
Psychotropic Drugs
0
Receptor, Metabotropic Glutamate 5
0
Glutamic Acid
3KX376GY7L
ebselen
40X2P7DPGH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22151Subventions
Organisme : Medical Research Council
ID : MR/K022733/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
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