A Review on Stem Cell Therapy for Neuropathic Pain.
Stem cell therapy
chronic pain
mesenchymal stem cells
neuropathic pain
neurotrophic factor
pain management.
Journal
Current stem cell research & therapy
ISSN: 2212-3946
Titre abrégé: Curr Stem Cell Res Ther
Pays: United Arab Emirates
ID NLM: 101272517
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
07
2019
revised:
16
09
2019
accepted:
25
11
2019
pubmed:
15
2
2020
medline:
4
2
2021
entrez:
15
2
2020
Statut:
ppublish
Résumé
Neuropathic pain is a complex, chronic pain state that is heterogeneous in nature and caused by the consequence of a lesion or disease affecting the somatosensory system. Current medications give a long-lasting pain relief only in a limited percentage of patients also associated with numerous side effects. Stem cell transplantation is one of the attractive therapeutic platforms for the treatment of a variety of diseases, such as neuropathic pain. Here, the authors review the therapeutic effects of stem cell transplantation of different origin and species in different models of neuropathic pain disorders. Stem cell transplantation could alleviate the neuropathic pain; indeed, stem cells are the source of cells, which differentiate into a variety of cell types and lead trophic factors to migrate to the lesion site opposing the effects of damage. In conclusion, this review suggests that stem cell therapy can be a novel approach for the treatment of neuropathic pain.
Identifiants
pubmed: 32056531
pii: CSCR-EPUB-104512
doi: 10.2174/1574888X15666200214112908
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
349-361Informations de copyright
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