Effects of nifedipine and sildenafil on placental hemodynamics and gas exchange during fetal hypoxemia in a chronic sheep model.
Blood flow
Fetus
Physiology
Pregnancy
Ultrasound
Journal
Placenta
ISSN: 1532-3102
Titre abrégé: Placenta
Pays: Netherlands
ID NLM: 8006349
Informations de publication
Date de publication:
15 01 2020
15 01 2020
Historique:
received:
29
09
2019
revised:
11
12
2019
accepted:
15
12
2019
entrez:
15
2
2020
pubmed:
15
2
2020
medline:
3
2
2021
Statut:
ppublish
Résumé
We hypothesized that nifedipine and sildenafil would have no detrimental effects on placental hemodynamics and gas exchange under fetal hypoxemia. In 33 chronically instrumented fetal sheep, placental volume blood flow (Q Hypoxemia significantly decreased fetal pO In fetal hypoxemia, sildenafil had detrimental effects on placental hemodynamics that disturbed placental gas exchange. Nifedipine did not alter placental hemodynamics in hypoxemia but disturbed placental gas exchange upon returning to normoxemia. Umbilical artery vascular impedance did not reflect alterations in placental hemodynamics.
Identifiants
pubmed: 32056540
pii: S0143-4004(19)30725-8
doi: 10.1016/j.placenta.2019.12.014
pii:
doi:
Substances chimiques
Vasodilator Agents
0
Sildenafil Citrate
BW9B0ZE037
Nifedipine
I9ZF7L6G2L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103-108Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None declared.