Differences in psychomotor activity and heart rate variability in patients with newly diagnosed bipolar disorder, unaffected relatives, and healthy individuals.
Activity energy expenditure
Bipolar disorder
Heart rate variability
Psychomotor activity
Unaffected relatives
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
08
09
2019
revised:
22
11
2019
accepted:
20
01
2020
pubmed:
15
2
2020
medline:
16
2
2021
entrez:
15
2
2020
Statut:
ppublish
Résumé
Heart rate variability (HRV) and psychomotor activity have been found reduced in bipolar disorder (BD) but has never been investigated in newly diagnosed BD and unaffected relatives. The present study aimed to compare HRV and psychomotor activity between newly diagnosed patients with BD, their unaffected first-degree relatives (UR), and healthy control individuals (HC). 20 newly diagnosed patients with BD, 20 of their UR, and 20 age- and sex-matched HC were included. Measurements of HRV for five minutes and heart rate and acceleration for seven days were conducted. Activity energy expenditure (AEE) was derived from the latter. Linear mixed effect regression models were conducted to compare the three groups. HRV did not differ in any measure between the three groups of participants. Similarly, AEE (kJ/day/kg) did not differ between the three groups in neither daily means (BD: 63.6, UR: 64.1, HC: 62.1) nor when divided into quarter-daily intervals. The relatively small size of the study may affect the validity of the results. Patients with newly diagnosed BD and UR do not present with decreased HRV or AEE. These results contrast prior findings from BD patients with more advanced stages of the disorder, suggesting that these outcomes progress with illness duration.
Sections du résumé
BACKGROUND
Heart rate variability (HRV) and psychomotor activity have been found reduced in bipolar disorder (BD) but has never been investigated in newly diagnosed BD and unaffected relatives. The present study aimed to compare HRV and psychomotor activity between newly diagnosed patients with BD, their unaffected first-degree relatives (UR), and healthy control individuals (HC).
METHODS
20 newly diagnosed patients with BD, 20 of their UR, and 20 age- and sex-matched HC were included. Measurements of HRV for five minutes and heart rate and acceleration for seven days were conducted. Activity energy expenditure (AEE) was derived from the latter. Linear mixed effect regression models were conducted to compare the three groups.
RESULTS
HRV did not differ in any measure between the three groups of participants. Similarly, AEE (kJ/day/kg) did not differ between the three groups in neither daily means (BD: 63.6, UR: 64.1, HC: 62.1) nor when divided into quarter-daily intervals.
LIMITATIONS
The relatively small size of the study may affect the validity of the results.
CONCLUSION
Patients with newly diagnosed BD and UR do not present with decreased HRV or AEE. These results contrast prior findings from BD patients with more advanced stages of the disorder, suggesting that these outcomes progress with illness duration.
Identifiants
pubmed: 32056891
pii: S0165-0327(19)32417-6
doi: 10.1016/j.jad.2020.01.110
pmc: PMC7116568
mid: EMS105857
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
30-36Subventions
Organisme : Medical Research Council
ID : MC_UU_00006/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12015/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12015/3
Pays : United Kingdom
Organisme : Department of Health
ID : IS-BRC-1215-20014
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest JF, SB and MFJ declare no conflicts of interest. LVK has within recent three years been a consultant for Lundbeck.
Références
J Appl Physiol (1985). 2007 Aug;103(2):682-92
pubmed: 17463305
Eur J Clin Nutr. 2008 Jun;62(6):704-11
pubmed: 17440515
Psychiatry Clin Neurosci. 2014 Sep;68(9):674-82
pubmed: 24612182
Bipolar Disord. 2003 Apr;5(2):138-43
pubmed: 12680904
Bipolar Disord. 2013 Feb;15(1):70-9
pubmed: 23237079
Int J Behav Nutr Phys Act. 2011 Oct 21;8:115
pubmed: 22018588
Psychiatry Res. 2016 Mar 30;237:279-81
pubmed: 26803363
BMJ Open. 2017 Jun 23;7(6):e015462
pubmed: 28645967
Am J Psychiatry. 2009 Feb;166(2):173-81
pubmed: 19122008
Eur J Clin Nutr. 2005 Apr;59(4):561-70
pubmed: 15714212
Bipolar Disord. 2011 Jun;13(4):387-95
pubmed: 21843278
Psychopathology. 1992;25(2):109-16
pubmed: 1502292
Int J Behav Nutr Phys Act. 2019 Dec 9;16(1):126
pubmed: 31818302
Clin Psychopharmacol Neurosci. 2013 Dec;11(3):137-43
pubmed: 24465250
Psychiatry Res. 2016 Mar 30;237:166-74
pubmed: 26832835
Br J Psychiatry. 2011 Oct;199(4):303-9
pubmed: 21508436
Br J Psychiatry. 1978 Nov;133:429-35
pubmed: 728692
Aust N Z J Psychiatry. 2016 Aug;50(8):793-804
pubmed: 27307288
Br J Soc Clin Psychol. 1967 Dec;6(4):278-96
pubmed: 6080235
PLoS One. 2015 Sep 08;10(9):e0137206
pubmed: 26349056
J Affect Disord. 2019 May 15;251:100-106
pubmed: 30921592
J Psychiatry Neurosci. 2016 Mar;41(2):89-104
pubmed: 26447819
J Affect Disord. 2015 Jul 15;180:142-7
pubmed: 25909752
J Affect Disord. 2012 May;138(3):440-8
pubmed: 22314261
Metab Brain Dis. 2014 Jun;29(2):367-75
pubmed: 24311196
Lancet. 2002 Feb 2;359(9304):431-4
pubmed: 11844534
Acta Psychiatr Scand. 2016 Jan;133(1):44-52
pubmed: 26371411
Arch Gen Psychiatry. 1971 Mar;24(3):215-20
pubmed: 5100617
J Psychiatr Res. 2010 Feb;44(3):168-76
pubmed: 19700172
Bipolar Disord. 2015 Aug;17(5):543-8
pubmed: 25846854
J Affect Disord. 2005 Apr;85(3):293-9
pubmed: 15780699
Pharmacopsychiatry. 1990 Jun;23 Suppl 4:183-7
pubmed: 2197646
J Nutr. 2006 Apr;136(4):1037-42
pubmed: 16549471
Front Physiol. 2013 Feb 20;4:26
pubmed: 23431279
Biomed Eng Online. 2011 Apr 12;10:27
pubmed: 21481282
Psychiatry Clin Neurosci. 2012 Jun;66(4):361-6
pubmed: 22624742
Schizophr Res. 2011 Sep;131(1-3):101-4
pubmed: 21741216
Eur Psychiatry. 2015 Feb;30(2):228-32
pubmed: 25555342
Psychiatry Res. 2014 Dec 30;220(3):890-5
pubmed: 25219620
Arch Gen Psychiatry. 1974 Jun;30(6):765-8
pubmed: 4832184
J Affect Disord. 2017 Jan 15;208:521-527
pubmed: 27816324
Neurosci Biobehav Rev. 2017 Feb;73:68-80
pubmed: 27986468
Arch Gen Psychiatry. 1990 Jun;47(6):589-93
pubmed: 2190539
Am J Psychiatry. 1997 Jan;154(1):4-17
pubmed: 8988952