Smart Protein-Based Formulation of Dendritic Mesoporous Silica Nanoparticles: Toward Oral Delivery of Insulin.
beta-lactoglobulin tablets
cellular insulin starvation
dendritic mesoporous silica nanoparticles
oral insulin dosage
transcellular epithelial transport
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
21 Apr 2020
21 Apr 2020
Historique:
received:
12
02
2020
pubmed:
15
2
2020
medline:
18
7
2020
entrez:
15
2
2020
Statut:
ppublish
Résumé
Oral insulin administration still represents a paramount quest that almost a century of continuous research attempts did not suffice to fulfill. Before pre-clinical development, oral insulin products have first to be optimized in terms of encapsulation efficiency, protection against proteolysis, and intestinal permeation ability. With the use of dendritic mesoporous silica nanoparticles (DMSNs) as an insulin host and together with a protein-based excipient, succinylated β-lactoglobulin (BL), pH-responsive tablets permitted the shielding of insulin from early release/degradation in the stomach and mediated insulin permeation across the intestinal cellular membrane. Following an original in vitro cellular assay based on insulin starvation, direct cellular fluorescent visualization has evidenced how DMSNs could ensure the intestinal cellular transport of insulin.
Identifiants
pubmed: 32057143
doi: 10.1002/chem.202000773
pmc: PMC7217061
doi:
Substances chimiques
Insulin
0
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5195-5199Subventions
Organisme : The University of Vienna, Austria
Informations de copyright
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
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