Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells.
Antiausterity agent
Drug discovery
Guggulsterone
PANC-1
Pancreatic cancer
Preferential cytotoxicity
Steroid
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
02
12
2019
revised:
08
01
2020
accepted:
09
01
2020
pubmed:
15
2
2020
medline:
1
4
2021
entrez:
15
2
2020
Statut:
ppublish
Résumé
E- and Z-guggulsterones and nine guggulsterone derivatives (GSDs) were synthesized and evaluated for their preferential cytotoxicity against human PANC-1 cell in nutrient deprived medium utilizing antiausterity strategy. Among the synthesized compounds, GSD-1 and GSD-7 showed potent cytotoxicity against PANC-1 cells under nutrient-deprived conditions in a concentration dependent manner, with a PC
Identifiants
pubmed: 32057581
pii: S0960-894X(20)30017-2
doi: 10.1016/j.bmcl.2020.126964
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Pregnenediones
0
pregna-4,17-diene-3,16-dione
A4PW148END
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
126964Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.