Bioenergetic restoration and neuroprotection after therapeutic targeting of mitoNEET: New mechanism of pioglitazone following traumatic brain injury.

Animals Brain Injuries, Traumatic / drug therapy Disease Models, Animal Energy Metabolism / drug effects Iron-Binding Proteins / genetics Male Membrane Proteins / genetics Mice Mice, Knockout Mitochondria / drug effects Neuroprotection / drug effects Neuroprotective Agents / pharmacology Pioglitazone / pharmacology Rats Rats, Sprague-Dawley
Beam walk Calcium overload Controlled cortical impact Mitochondrial bioenergetics NL-1 Novel object recognition Seahorse

Journal

Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712

Informations de publication

Date de publication:
05 2020
Historique:
received: 28 10 2019
revised: 13 01 2020
accepted: 09 02 2020
pubmed: 15 2 2020
medline: 28 10 2020
entrez: 15 2 2020
Statut: ppublish

Résumé

Mitochondrial dysfunction is a pivotal event in many neurodegenerative disease states including traumatic brain injury (TBI) and spinal cord injury (SCI). One possible mechanism driving mitochondrial dysfunction is glutamate excitotoxicity leading to Ca

Identifiants

DOI: 10.1016/j.expneurol.2020.113243 PMID: 32057797 PMC: PMC7089834
pubmed: 32057797
pii: S0014-4886(20)30074-1
doi: 10.1016/j.expneurol.2020.113243
pmc: PMC7089834
mid: NIHMS1565546
pii:
doi:

Substances chimiques

Iron-Binding Proteins 0
Membrane Proteins 0
Neuroprotective Agents 0
mitoNEET protein, mouse 0
Pioglitazone X4OV71U42S

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

113243

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR000117
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM109098
Pays : United States
Organisme : BLRD VA
ID : I01 BX003405
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104942
Pays : United States
Organisme : NIH HHS
ID : S10 OD023573
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001998
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS086395
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

Références

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Auteurs

Heather M Yonutas (HM)

Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA. Electronic address: heather.yonutas@yahoo.com.

W Brad Hubbard (WB)

Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA; Lexington VA Healthcare System, Lexington, KY 40502, USA. Electronic address: bradhubbard@uky.edu.

Jignesh D Pandya (JD)

Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Currently Research Biologist, Brain Trauma Neuroprotection and Neurorestoration (BTNN) Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA. Electronic address: jignesh.d.pandya.civ@mail.mil.

Hemendra J Vekaria (HJ)

Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA. Electronic address: hemendravekaria@uky.edu.

Werner J Geldenhuys (WJ)

Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown 26501, USA. Electronic address: werner.geldenhuys@hsc.wvu.edu.

Patrick G Sullivan (PG)

Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA; Lexington VA Healthcare System, Lexington, KY 40502, USA. Electronic address: patsullivan@uky.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Lésions traumatiques de l'encéphale › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neuroprotection › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Thiazoles › Thiazolidinediones › Pioglitazone › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Bioenergetic restoration and neuroprotection...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Bioenergetic restoration and neuroprotection...