ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans.
ATP Binding Cassette Transporter, Subfamily B
/ genetics
Adult
Aged
Aged, 80 and over
Case-Control Studies
Chile
/ epidemiology
Europe
/ epidemiology
Female
Gallbladder Neoplasms
/ epidemiology
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Indians, South American
/ genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Prospective Studies
Retrospective Studies
White People
/ genetics
Cancer epidemiology
Gallbladder cancer
Native American ancestry
Population-specific risk marker
Journal
Cancer epidemiology
ISSN: 1877-783X
Titre abrégé: Cancer Epidemiol
Pays: Netherlands
ID NLM: 101508793
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
20
09
2019
revised:
08
11
2019
accepted:
15
11
2019
pubmed:
15
2
2020
medline:
17
9
2020
entrez:
15
2
2020
Statut:
ppublish
Résumé
The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.
Sections du résumé
BACKGROUND
The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence.
METHODS
This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.
RESULTS
Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.
CONCLUSION
Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.
Identifiants
pubmed: 32058310
pii: S1877-7821(19)30153-5
doi: 10.1016/j.canep.2019.101643
pii:
doi:
Substances chimiques
ABCB1 protein, human
0
ATP Binding Cassette Transporter, Subfamily B
0
multidrug resistance protein 3
9EI49ZU76O
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101643Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.