Inhibitory effects of neurotoxin β-N-methylamino-L-alanine on fertilization and early development of the sea urchin Lytechinus pictus.
Amino Acids, Diamino
/ toxicity
Animals
Aquatic Organisms
/ drug effects
Cyanobacteria Toxins
Embryo, Nonmammalian
/ drug effects
Embryonic Development
/ drug effects
Fertilization
/ drug effects
Humans
Larva
/ drug effects
Lytechinus
/ drug effects
Male
Neurotoxins
/ toxicity
Spermatozoa
/ drug effects
Water Pollutants, Chemical
/ toxicity
Efflux assay
Embryonic development
Lytechinus pictus
Malformation
Sea urchin
β-N-methylamino-L-alanine (BMAA)
Journal
Aquatic toxicology (Amsterdam, Netherlands)
ISSN: 1879-1514
Titre abrégé: Aquat Toxicol
Pays: Netherlands
ID NLM: 8500246
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
14
12
2019
revised:
27
01
2020
accepted:
27
01
2020
pubmed:
15
2
2020
medline:
12
5
2020
entrez:
15
2
2020
Statut:
ppublish
Résumé
Neurotoxin β-N-methylamino-L-alanine (BMAA) has been widely detected in diverse aquatic organisms and hypothesized as an environmental risk to neurodegenerative diseases in humans. However, the knowledge of its toxicity to marine organisms requires attention. In the present study, embryos and sperm of the sea urchin, Lytechinus pictus, were used to assess the toxicity of BMAA. Effects of BMAA on fertilization and development of sea urchin embryos were measured, and its impacts on efflux transport of sea urchin blastula were also assayed. Results demonstrated that the fertilization and development of embryos were significantly inhibited by high concentrations of BMAA above 300 μg L
Identifiants
pubmed: 32058875
pii: S0166-445X(19)31053-7
doi: 10.1016/j.aquatox.2020.105425
pii:
doi:
Substances chimiques
Amino Acids, Diamino
0
Cyanobacteria Toxins
0
Neurotoxins
0
Water Pollutants, Chemical
0
beta-N-methylamino-L-alanine
108SA6URTV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105425Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.