A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
14 02 2020
14 02 2020
Historique:
received:
06
12
2018
revised:
06
10
2019
accepted:
09
01
2020
entrez:
16
2
2020
pubmed:
16
2
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
IL-13 and IL-4 are potent mediators of type 2-associated inflammation such as those found in atopic dermatitis (AD). IL-4 shares overlapping biological functions with IL-13, a finding that is mainly explained by their ability to signal via the type 2 IL-4 receptor (R), which is composed of IL-4Rα in association with IL-13Rα1. Nonetheless, the role of the type 2 IL-4R in AD remains to be clearly defined. Induction of two distinct models of experimental AD in
Identifiants
pubmed: 32060143
pii: 5/44/eaaw2938
doi: 10.1126/sciimmunol.aaw2938
pii:
doi:
Substances chimiques
Interleukin-13
0
Receptors, Interleukin-4, Type II
0
Oxazolone
15646-46-5
Dinitrofluorobenzene
D241E059U6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.