CCL21 Programs Immune Activity in Tumor Microenvironment.

Animals Chemokine CCL21 / immunology Dendritic Cells / immunology Humans Immunotherapy Neoplasms / immunology T-Lymphocytes / immunology Tumor Escape / immunology Tumor Microenvironment / immunology
Activated T cells Antigen-presenting cells CCL21 Dendritic cells Immune activity Immune checkpoint blockade Immune suppression Immunotherapy Programmed cell death protein 1 (PD-1) T cells Tumor microenvironment

Journal

Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103

Informations de publication

Date de publication:
2020
Historique:
entrez: 16 2 2020
pubmed: 16 2 2020
medline: 28 2 2020
Statut: ppublish

Résumé

CCL21 promotes immune activity in the tumor microenvironment (TME) by colocalizing dendritic cells (DC) and T cells programing ectopic lymph node architectural structures that correlate with cancer prognosis. Innovative strategies to deliver CCL21 in cancer patients will reactivate the downregulated immune activity in the TME. Immune escape mechanisms are upregulated in the TME that promote tumor immune evasion. CCL21 combined with inhibition of dominant pathways of immune evasion will aid in the development of effective immunotherapy for cancer.

Identifiants

DOI: 10.1007/978-3-030-36667-4_7 PMID: 32060847
pubmed: 32060847
doi: 10.1007/978-3-030-36667-4_7
doi:

Substances chimiques

CCL21 protein, human 0
Chemokine CCL21 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

67-78

Auteurs

Sherven Sharma (S)

Department of Medicine, UCLA Lung Cancer Research Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. SSharma@mednet.ucla.edu.
Molecular Gene Medicine Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA. SSharma@mednet.ucla.edu.
Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. SSharma@mednet.ucla.edu.

Pournima Kadam (P)

Molecular Gene Medicine Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

Steven Dubinett (S)

Department of Medicine, UCLA Lung Cancer Research Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Molecular Gene Medicine Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › CCL21 Programs Immune Activity in Tumor...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CC › Chimiokine CCL21 › CCL21 Programs Immune Activity in Tumor...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › CCL21 Programs Immune Activity in Tumor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CCL21 Programs Immune Activity in Tumor...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › CCL21 Programs Immune Activity in Tumor...
questionsmedicales.fr › Tumeurs › CCL21 Programs Immune Activity in Tumor...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › CCL21 Programs Immune Activity in Tumor...
questionsmedicales.fr › Phénomènes du système immunitaire › Échappement de la tumeur à la surveillance immunitaire › CCL21 Programs Immune Activity in Tumor...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › CCL21 Programs Immune Activity in Tumor...