Medicinal chemistry strategies toward host targeting antiviral agents.
broad-spectrum antivirals
direct-acting antiviral agents
drug resistance
host targeting antiviral agents
Journal
Medicinal research reviews
ISSN: 1098-1128
Titre abrégé: Med Res Rev
Pays: United States
ID NLM: 8103150
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
07
11
2019
revised:
23
01
2020
accepted:
29
01
2020
pubmed:
16
2
2020
medline:
29
10
2021
entrez:
16
2
2020
Statut:
ppublish
Résumé
Direct-acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and have been demonstrated to be very successful in combating viral infections in clinic. However, DAAs suffer from several inherent limitations, including narrow-spectrum antiviral profiles and liability to drug resistance, and hence there are still unmet needs in the treatment of viral infections. In comparison, host targeting antivirals (HTAs) target host factors for antiviral treatment. Since host proteins are probably broadly required for various viral infections, HTAs are not only perceived, but also demonstrated to exhibit broad-spectrum antiviral activities. In addition, host proteins are not under the genetic control of viral genome, and hence HTAs possess much higher genetic barrier to drug resistance as compared with DAAs. In recent years, much progress has been made to the development of HTAs with the approval of chemokine receptor type 5 antagonist maraviroc for human immunodeficiency virus treatment and more in the pipeline for other viral infections. In this review, we summarize various host proteins as antiviral targets from a medicinal chemistry prospective. Challenges and issues associated with HTAs are also discussed.
Identifiants
pubmed: 32060956
doi: 10.1002/med.21664
pmc: PMC7228277
doi:
Substances chimiques
Antiviral Agents
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1519-1557Informations de copyright
© 2020 Wiley Periodicals, Inc.
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