Cobalt nanoparticles trigger ferroptosis-like cell death (oxytosis) in neuronal cells: Potential implications for neurodegenerative disease.
cobalt
ferroptosis
hard metal
nanoparticles
neurodegeneration
oxytosis
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
27
08
2019
revised:
23
01
2020
accepted:
01
02
2020
pubmed:
16
2
2020
medline:
20
1
2021
entrez:
16
2
2020
Statut:
ppublish
Résumé
The neurotoxicity of hard metal-based nanoparticles (NPs) remains poorly understood. Here, we deployed the human neuroblastoma cell line SH-SY5Y differentiated or not into dopaminergic- and cholinergic-like neurons to study the impact of tungsten carbide (WC) NPs, WC NPs sintered with cobalt (Co), or Co NPs versus soluble CoCl
Identifiants
pubmed: 32060981
doi: 10.1096/fj.201902191RR
doi:
Substances chimiques
Cobalt
3G0H8C9362
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5262-5281Informations de copyright
© 2020 Karolinska Institutet. The FASEB Journal published by Wiley Periodicals, Inc. on behalf of Federation of American Societies for Experimental Biology.
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