Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases.
Antioxidant systems
Diabetes
Obesity
Rhodanese
Sulfurtransferase
TST
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
28
08
2019
revised:
10
01
2020
accepted:
30
01
2020
pubmed:
18
2
2020
medline:
21
10
2020
entrez:
17
2
2020
Statut:
ppublish
Résumé
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.
Identifiants
pubmed: 32061776
pii: S0925-4439(20)30061-2
doi: 10.1016/j.bbadis.2020.165716
pii:
doi:
Substances chimiques
Antioxidants
0
Iron-Sulfur Proteins
0
TXN protein, human
0
Thioredoxins
52500-60-4
Sulfur
70FD1KFU70
Thiosulfate Sulfurtransferase
EC 2.8.1.1
Glutathione
GAN16C9B8O
Selenium
H6241UJ22B
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
165716Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.