The multifarious lysozyme arsenal of Dictyostelium discoideum.
Amoeba
Dictyostelium discoideum
Lysozymes
Phylogenetic distribution
Protozoa
Journal
Developmental and comparative immunology
ISSN: 1879-0089
Titre abrégé: Dev Comp Immunol
Pays: United States
ID NLM: 7708205
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
09
01
2020
revised:
12
02
2020
accepted:
12
02
2020
pubmed:
18
2
2020
medline:
25
6
2021
entrez:
17
2
2020
Statut:
ppublish
Résumé
Dictyostelium discoideum is a free-living soil amoeba which feeds upon bacteria. To bind, ingest, and kill bacteria, D. discoideum uses molecular mechanisms analogous to those found in professional phagocytic cells of multicellular organisms. D. discoideum is equipped with a large arsenal of antimicrobial peptides and proteins including amoebapore-like peptides and lysozymes. This review describes the family of lysozymes in D. discoideum. We identified 22 genes potentially encoding four different types of lysozymes in the D. discoideum genome. Although most of these genes are also present in the genomes of other amoebal species, no other organism is as well-equipped with lysozyme genes as D. discoideum.
Identifiants
pubmed: 32061941
pii: S0145-305X(20)30011-2
doi: 10.1016/j.dci.2020.103645
pii:
doi:
Substances chimiques
Ion Channels
0
Pore Forming Cytotoxic Proteins
0
Protozoan Proteins
0
amoebapore proteins, protozoan
0
Muramidase
EC 3.2.1.17
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103645Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no competing or financial interests.