The role of Thallium-201 scintigraphy and Tc-99m pentavalent dimercaptosuccinic acid in diagnosis and grading of chondrosarcoma.
Adolescent
Adult
Aged
Aged, 80 and over
Bone Neoplasms
/ diagnostic imaging
Chondroma
/ diagnostic imaging
Chondrosarcoma
/ diagnostic imaging
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Neoplasm Grading
Radionuclide Imaging
Radiopharmaceuticals
Reproducibility of Results
Technetium Tc 99m Dimercaptosuccinic Acid
Thallium Radioisotopes
Young Adult
Cartilaginous tumours
Chondrosarcoma
Diagnostic imaging
Functional imaging
Pentavalent dimercaptosuccinic acid
Thallium-201
Journal
European journal of radiology
ISSN: 1872-7727
Titre abrégé: Eur J Radiol
Pays: Ireland
ID NLM: 8106411
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
27
05
2019
revised:
02
12
2019
accepted:
16
01
2020
pubmed:
18
2
2020
medline:
30
10
2020
entrez:
17
2
2020
Statut:
ppublish
Résumé
Distinguishing between enchondromas and low-grade (grade 1) chondrosarcomas can be challenging. The aim of this study was to investigate the role of Thallium-201 scintigraphy and Technetium-99 m pentavalent dimercaptosuccinic acid (Tc-99 m DMSA (V)) in the diagnosis and grading of chondrosarcomas. 232 consecutive patients with pathologically proven cartilaginous tumours between the years 2000 and 2018 were evaluated. We included 197 patients (101 males and 96 females; median age 50 years; range 15-86 years) who underwent Thallium-201(n = 193) and/or Tc-99 m DMSA (V) scanning (n = 67). Increased uptake was defined as uptake greater than background. The reference standard was the histopathological assessment based on a grading system (grade 1-3). Data was analysed using multivariate modelling. There were 46 patients with enchondromas and 151 with chondrosarcomas. Of those, 64 (enchondroma n = 21, chondrosarcoma n = 43) underwent both Thallium-201 and Tc-99 m DMSA (V). Thallium-201 uptake had 7.92 times greater odds of grade 1 chondrosarcomas than enchondromas. Thallium-201 uptake was significantly associated with the odds of a higher grade chondrosarcoma (grade 2-3). DMSA (V) positivity was associated with 4.75 times the odds of a chondrosarcoma diagnosis over enchondroma (p = 0.024). DMSA (V) uptake revealed no association with chondrosarcoma grading. Low-grade chondrosarcomas continue to pose a diagnostic dilemma. Thallium-201 scans may identify malignancy in benign appearing tumours as well as differentiate between low-grade and high-grade chondrosarcomas in said malignancies. DMSA (V) may be useful in distinguishing between benign and malignant entities as a whole.
Identifiants
pubmed: 32062570
pii: S0720-048X(20)30035-8
doi: 10.1016/j.ejrad.2020.108846
pii:
doi:
Substances chimiques
Radiopharmaceuticals
0
Thallium Radioisotopes
0
Technetium Tc 99m Dimercaptosuccinic Acid
494JNQ8L28
Thallium-201
H91Z8HBK1B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108846Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest I Jo declares that she has no conflict of interest. S Schlitch declares that he has no conflict of interest. G Powell declares that he has no conflict of interest. C Di Bella declares that she has no conflict of interest. G Pang declares that he has no conflict of interest. T Spelman declare that he has no conflict of interest. PF Choong has received institutional research grants from Johnson & Johnson P/L and Medacta AB, and is a member of the Surgeon Advisory Board for Oncology for Stryker Corporation.