Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity.

Animals Antineoplastic Agents / pharmacology Apoptosis / drug effects Biological Products / pharmacology Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Humans Neoplasms / drug therapy Porifera Protein Kinase Inhibitors / pharmacology Receptor, Platelet-Derived Growth Factor beta / antagonists & inhibitors Turkey Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors
Apoptosis Cancer Marine products Tyrosine kinase inhibitors

Journal

Investigational new drugs
ISSN: 1573-0646
Titre abrégé: Invest New Drugs
Pays: United States
ID NLM: 8309330

Informations de publication

Date de publication:
10 2020
Historique:
received: 06 01 2020
accepted: 10 02 2020
pubmed: 18 2 2020
medline: 15 9 2021
entrez: 17 2 2020
Statut: ppublish

Résumé

Marine natural products have drawn a great deal of attention as a vital source of new drugs for the last five decades. However, marine organisms in the seas surrounding Turkey (the Black Sea, the Aegean Sea and the Mediterranean Sea) haven't been yet extensively explored. In the present study, three marine organisms (Dysidea avara, Microcosmus sabatieri and Echinaster sepositus) were sampled from the Dardanelles (Turkish Straits System, Western Turkey) by scientific divers, transferred to the laboratory and then were extracted with 70% ethanol. The extracts were tested for their cytotoxic effect against K562, KMS-12PE, A549, and A375 cancer cell lines. The sponge extract elicited the most promising cytotoxic activity, thus it was further evaluated against H929, MCF-7, HeLa, and HCT116 cancer cells. Most of the designated cells showed a considerable sensitivity for the sponge extract particularly H929, K562, KMS-12PE and HeLa cells with IC

Identifiants

DOI: 10.1007/s10637-020-00911-8 PMID: 32062733
pubmed: 32062733
doi: 10.1007/s10637-020-00911-8
pii: 10.1007/s10637-020-00911-8
doi:

Substances chimiques

Antineoplastic Agents 0
Biological Products 0
Protein Kinase Inhibitors 0
KDR protein, human EC 2.7.10.1
PDGFRB protein, human EC 2.7.10.1
Receptor, Platelet-Derived Growth Factor beta EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-2 EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1326-1333

Références

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Auteurs

Halil I Ciftci (HI)

Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan.
Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan.

Mustafa Can (M)

Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan.
Department of Engineering Sciences, Faculty of Engineering and Architecture, Izmir Katip Celebi University, Havaalani Sosesi Caddesi No:25, 35620, Cigli/Izmir, Turkey.

Doha E Ellakwa (DE)

Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan.
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Al-Azhar University, Greater Cairo, Nasr City, 11651, Egypt.

Salih C Suner (SC)

Chemical and Chemical Processing, Vocational School of Lapseki, Canakkale Onsekiz Mart University, 17800, Canakkale, Turkey.

Mohamed A Ibrahim (MA)

Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, 12622, Egypt.

Ayhan Oral (A)

Department of Chemistry, Faculty of Science, Canakkale Onsekiz Mart University, 17020, Canakkale, Turkey.

Nazim Sekeroglu (N)

Department of Horticulture, Faculty of Agriculture, Kilis 7 Aralik University, 79000, Kilis, Turkey.

Barış Özalp (B)

Section of Underwater Technology, Vocational School of Ocean Engineering, Canakkale Onsekiz Mart University, 17100, Canakkale, Turkey.

Masami Otsuka (M)

Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan.
Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan.

Mikako Fujita (M)

Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan. mfujita@kumamoto-u.ac.jp.

Mustafa Alparslan (M)

Faculty of Fisheries and Aquaculture, Izmir Katip Celebi University, 35620, Izmir, Turkey. m_alparslan@hotmail.com.

Mohamed O Radwan (MO)

Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan. mohamedradwan@kumamoto-u.ac.jp.
Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan. mohamedradwan@kumamoto-u.ac.jp.
Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, 12622, Egypt. mohamedradwan@kumamoto-u.ac.jp.
ORCID: 0000-0002-9220-2659

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Anticancer activity of Turkish marine...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Anticancer activity of Turkish marine...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Anticancer activity of Turkish marine...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Anticancer activity of Turkish marine...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Anticancer activity of Turkish marine...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Anticancer activity of Turkish marine...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Anticancer activity of Turkish marine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Anticancer activity of Turkish marine...
questionsmedicales.fr › Tumeurs › Anticancer activity of Turkish marine...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Porifera › Anticancer activity of Turkish marine...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Anticancer activity of Turkish marine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance dérivés des plaquettes › Récepteur au PDGF bêta › Anticancer activity of Turkish marine...
questionsmedicales.fr › Régions géographiques › Asie › Asie de l'Ouest › Moyen Orient › Turquie › Anticancer activity of Turkish marine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance endothéliale vasculaire › Récepteur-2 au facteur croissance endothéliale vasculaire › Anticancer activity of Turkish marine...