Mathematical Modelling of Alternative Pathway of Complement System.
Alternative pathway
C3 glomerulopathy
Complement system
Immunology
Journal
Bulletin of mathematical biology
ISSN: 1522-9602
Titre abrégé: Bull Math Biol
Pays: United States
ID NLM: 0401404
Informations de publication
Date de publication:
15 02 2020
15 02 2020
Historique:
received:
07
06
2019
accepted:
03
02
2020
entrez:
17
2
2020
pubmed:
18
2
2020
medline:
24
3
2021
Statut:
epublish
Résumé
The complement system (CS) is an integral part of innate immunity and can be activated via three different pathways. The alternative pathway (AP) has a central role in the function of the CS. The AP of complement system is implicated in several human disease pathologies. In the absence of triggers, the AP exists in a time-invariant resting state (physiological steady state). It is capable of rapid, potent and transient activation response upon challenge with a trigger. Previous models of AP have focused on the activation response. In order to understand the molecular machinery necessary for AP activation and regulation of a physiological steady state, we built parsimonious AP models using experimentally supported kinetic parameters. The models further allowed us to test quantitative roles played by negative and positive regulators of the pathway in order to test hypotheses regarding their mechanisms of action, thus providing more insight into the complex regulation of AP.
Identifiants
pubmed: 32062771
doi: 10.1007/s11538-020-00708-z
pii: 10.1007/s11538-020-00708-z
pmc: PMC7024062
doi:
Substances chimiques
Properdin
11016-39-0
Complement C3b
80295-43-8
Complement Factor H
80295-65-4
Complement Factor B
EC 3.4.21.47
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
33Commentaires et corrections
Type : ErratumIn
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