Anti-genotoxic and anti-mutagenic effects of melatonin supplementation in a mouse model of melanoma.
B16F10 cells
DNA damage
Melanoma
comet assay
genotoxicity
melatonin
micronucleus test
mutagenicity
skin cancer
Journal
Drug and chemical toxicology
ISSN: 1525-6014
Titre abrégé: Drug Chem Toxicol
Pays: United States
ID NLM: 7801723
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
pubmed:
18
2
2020
medline:
24
2
2022
entrez:
18
2
2020
Statut:
ppublish
Résumé
Melanoma, an aggressive skin cancer originating from melanocytes, can metastasize to the lungs, liver, cortex, femur, and spinal cord, ultimately resulting in DNA mutagenic effects. Melatonin is an endogenous hormone and free radical scavenger that possesses the ability to protect the DNA and to exert anti-proliferative effects in melanoma cells. The aim of this study was to evaluate the effects of B16F10 melanoma cells and the effects of melatonin supplementation on genotoxic parameters in murine melanoma models. Thirty-two male C57Bl/6 mice were divided in the following four groups: PBS + vehicle (
Identifiants
pubmed: 32063063
doi: 10.1080/01480545.2020.1726380
doi:
Substances chimiques
Antimutagenic Agents
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM