Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.
Animals
Bexarotene
/ pharmacology
Cardiotonic Agents
/ pharmacology
Cardiotoxicity
/ drug therapy
Disease Models, Animal
Endothelial Cells
/ drug effects
Heart
/ drug effects
Humans
Isotretinoin
/ pharmacology
Myocardium
/ metabolism
Neoplasms
/ complications
Pericardium
/ drug effects
Retinoid X Receptor alpha
/ agonists
Zebrafish
Zonula Occludens-1 Protein
/ genetics
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
06
06
2019
accepted:
22
11
2019
entrez:
18
2
2020
pubmed:
18
2
2020
medline:
20
11
2020
Statut:
epublish
Résumé
To uncover the genetic basis of anthracycline-induced cardiotoxicity (AIC), we recently established a genetic suppressor screening strategy in zebrafish. Here, we report the molecular and cellular nature of
Identifiants
pubmed: 32064346
doi: 10.1126/sciadv.aay2939
pii: aay2939
pmc: PMC6989136
doi:
Substances chimiques
Cardiotonic Agents
0
RXRA protein, human
0
Retinoid X Receptor alpha
0
Zonula Occludens-1 Protein
0
Bexarotene
A61RXM4375
Isotretinoin
EH28UP18IF
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaay2939Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL081753
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002379
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL107304
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111437
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM063904
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG006431
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002377
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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