Attenuation of the inflammatory response and polarization of macrophages by photobiomodulation.
Animals
Cell Polarity
/ radiation effects
Cell Survival
/ radiation effects
Chemokines
/ genetics
Gene Expression Regulation
/ radiation effects
Inflammation
/ radiotherapy
Macrophage Activation
/ radiation effects
Macrophages
/ pathology
Mice, Inbred BALB C
Phosphorylation
/ radiation effects
RNA, Messenger
/ genetics
Reactive Oxygen Species
/ metabolism
Transcription Factor RelA
/ metabolism
Inflammation
Macrophage
Photobiomodulation
Polarization
Spinal cord injury
Journal
Lasers in medical science
ISSN: 1435-604X
Titre abrégé: Lasers Med Sci
Pays: England
ID NLM: 8611515
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
13
02
2019
accepted:
22
12
2019
pubmed:
18
2
2020
medline:
20
9
2020
entrez:
18
2
2020
Statut:
ppublish
Résumé
In spinal cord injury (SCI), inflammation is a major mediator of damage and loss of function and is regulated primarily by the bone marrow-derived macrophages (BMDMs). Photobiomodulation (PBM) or low-level light stimulation is known to have anti-inflammatory effects and has previously been used in the treatment of SCI, although its precise cellular mechanisms remain unclear. In the present study, the effect of PBM at 810 nm on classically activated BMDMs was evaluated to investigate the mechanisms underlying its anti-inflammatory effects. BMDMs were cultured and irradiated (810 nm, 2 mW/cm
Identifiants
pubmed: 32065300
doi: 10.1007/s10103-019-02941-y
pii: 10.1007/s10103-019-02941-y
doi:
Substances chimiques
Chemokines
0
RNA, Messenger
0
Reactive Oxygen Species
0
Transcription Factor RelA
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1509-1518Subventions
Organisme : National Natural Science Foundation of China
ID : 81572151
Organisme : Key Science and Technology Program in Social Development of Shaanxi Province
ID : 2016SF-143