Elaeocarpus reticulatus fruit extracts reduce viability and induce apoptosis in pancreatic cancer cells in vitro.
Antineoplastic Agents, Phytogenic
/ chemistry
Apoptosis
/ drug effects
Cell Cycle
/ drug effects
Cell Line, Tumor
Cell Survival
/ drug effects
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
Elaeocarpaceae
/ chemistry
Fruit
/ chemistry
Humans
Pancreatic Neoplasms
Plant Extracts
/ chemistry
Triterpenes
/ chemistry
Apoptosis
Cucurbitacin I
Elaeocarpus reticulatus
Pancreatic cancer
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
10
05
2019
accepted:
06
02
2020
pubmed:
18
2
2020
medline:
21
10
2020
entrez:
18
2
2020
Statut:
ppublish
Résumé
Treatment options for pancreatic cancer (PC) are severely limited due to late diagnosis, early metastasis and the inadequacy of chemotherapy and radiotherapy to combat the aggressive biology of the disease. In recent years, plant-derived bioactive compounds have emerged as a source of novel, anti-cancer agents. Used in traditional medicine worldwide, Elaeocarpus species have reported anti-inflammatory, antioxidant and anti-cancer properties. This study aimed to isolate and identify potential anti-PC compounds in the fruit of Elaeocarpus reticulatus Sm. A 50% acetone crude extract significantly decreased the viability of four pancreatic cell lines (≥ 10 µg/mL for BxPC-3 cells) and induced apoptosis in BxPC-3 and HPDE cells. Analysis by HPLC identified the triterpenoid Cucurbitacin I as a likely component of the extract. Furthermore, treatment with Cucurbitacin I significantly reduced the viability of HPDE and BxPC-3 cells, with results comparable to the same concentration of gemcitabine. Interestingly, attempts to isolate bioactive compounds revealed that the crude extract was more effective at reducing PC-cell viability than the fractionated extracts. This study provides initial insight into the bioactive constituents of E. reticulatus fruits.
Identifiants
pubmed: 32065323
doi: 10.1007/s11033-020-05307-8
pii: 10.1007/s11033-020-05307-8
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Plant Extracts
0
Triterpenes
0
cucurbitacin I
SHQ47990PH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2073-2084Références
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