Melanoma of the External Auditory Canal: A Review of Seven Cases at a Tertiary Care Referral Center.
Melanoma
auricular melanoma
external auditory canal
otologic malignancies
sentinel lymph node biopsy.
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
12
08
2019
revised:
23
12
2019
accepted:
16
01
2020
pubmed:
18
2
2020
medline:
22
1
2021
entrez:
18
2
2020
Statut:
ppublish
Résumé
Examine the presentation and management characteristics of seven patients with melanoma of the external auditory canal (EAC). Retrospective case series and review of the relevant literature. Records of seven patients from 2003 to 2017 with melanoma of the EAC were reviewed for characteristics of presentation, subsequent management, and outcomes. A thorough review of relevant literature is presented. The median age is 52 years, with four females. The average Breslow depth was 3.6 mm, with five patients having a Clark level IV or greater on presentation. Six patients underwent lateral temporal bone resection, and one patient underwent wide local excision of the cartilaginous canal. Sentinel lymph node biopsy (SLNB) was performed in three patients. Three patients experienced distant recurrence an average of 20 months following primary therapy. Median follow-up was 21 months. At last follow-up, four were free of disease, one had active disease, and two were deceased from melanoma. This is the largest series and the first to report the use of SLNB for patients with EAC melanoma in the peer-reviewed literature. Patients with external auditory canal melanoma present with higher Breslow thickness and stage relative to all external ear melanomas. Management should include wide local excision, which entails lateral temporal bone resection when the bony ear canal is involved. SLNB has a critical role in identifying patients with early metastatic disease. Postoperative radiation therapy should be considered for patients with high-risk features to reduce the risk of locoregional relapse. Chemotherapy, and especially immunotherapy, has an emerging role for this disease. 4 Laryngoscope, 131:165-172, 2021.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
165-172Informations de copyright
© 2020 The American Laryngological, Rhinological and Otological Society, Inc.
Références
PDQ Adult Treatment Editorial Board. Melanoma treatment (PDQ®): health professional version. PDQ Cancer Information Summaries. Bethesda, MD: National Cancer Institute; 2002 Available at: http://www.ncbi.nlm.nih.gov/books/NBK66034/. Accessed March 7, 2019.
American Cancer Society. Cancer Facts & Figures 2019. Atlanta, GA: American Cancer Society, 2019.
Ravin AG, Pickett N, Johnson JL, Fisher SR, Levin LS, Seigler HF. Melanoma of the ear: treatment and survival probabilities based on 199 patients. Ann Plast Surg 2006;57:70-76.
O'Brien CJ, Coates AS, Petersen-Schaefer K, et al. Experience with 998 cutaneous melanomas of the head and neck over 30 years. Am J Surg 1991;162:310-314.
Pack GT, Conley J, Oropeza R. Melanoma of the external ear. Arch Otolaryngol 1970;92:106-113.
Byers RM, Smith JL, Russell N, Rosenberg V. Malignant melanoma of the external ear. Review of 102 cases. Am J Surg 1980;140:518-521.
Green AC, Kimlin M, Siskind V, Whiteman DC. Hypothesis: hair cover can protect against invasive melanoma on the head and neck (Australia). Cancer Causes Control 2006;17:1263-1266.
Hawkes JE, Truong A, Meyer LJ. Genetic predisposition to melanoma. Semin Oncol 2016;43:591-597.
Conley J, Schuller DE. Malignancies of the ear. Laryngoscope 1976;86:1147-1163.
Langman AW, Yarington CT, Patterson SD. Malignant melanoma of the external auditory canal. Otolaryngol Head Neck Surg 1996;114:645-648.
Milbrath MMMD, Campbell BHMD, Madiedo GMD, Janjan NAMD. Malignant melanoma of the external auditory canal. J Clin Oncol 1998;21:28-30.
Amando García L, Suárez Nieto C, Madrigal Rubiales B, García García J. Melanoma de conducto auditivo externo. Acta Otorrinolaringol Esp 2003;54:89-93.
Hynes B, Lubynski RA, Hynes B. Malignant melanoma of the external ear canal: a rare case. J Otolaryngol 2004;33:401-403.
Banerjee AR, Meikle D, Dawes PJ, Deans JA. Malignant melanoma of the external auditory meatus. Clin Oncol (R Coll Radiol) 1993;5:255-256.
Kang S, Barnhill RL, Graeme-Cook F, Randolph G, Nadol JB, Sober AJ. Primary malignant melanoma of the external auditory canal: a case report with presentation as an aural polyp. Am J Otol 1992;13:194-196.
Sambe S, Kobayashi K, Asakura K, Kataura A. A case of malignant melanoma in the external auditory canal followed by systemic vasculitis. Nippon Jibiinkoka Gakkai Kaiho 1985;88:455-462.
Olariu B, Olariu D, Jianu S, Albăstroiu F, Ciuchi V, Laky D. Malignant melanoma of the external auditory canal treated by cryotherapy [in Romanian]. Rev Chir Oncol Radiol O R L Oftalmol Stomatol Otorinolaringol 1984;29:299-311.
Landau DC, Caruso Territoriale A, Garay IS, Kurpis M, Ruiz Lascano A. Melanoma in external auditory canal: regarding a case report. Med Cutan Iber Lat Am 2018;46:120-123.
Hannan SA, Parikh A. Malignant melanoma of the external ear canal. Lancet 2006;368:1680.
Bonnen MD, Ballo MT, Myers JN, et al. Elective radiotherapy provides regional control for patients with cutaneous melanoma of the head and neck. Cancer 2004;100:383-389.
Agrawal S, Kane JM, Guadagnolo BA, Kraybill WG, Ballo MT. The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high-risk, lymph node-metastatic melanoma. Cancer 2009;115:5836-5844.
Gershenwald JE, Scolyer RA, Hess KR. et al; American Joint Committee on Cancer Melanoma Expert Panel and the International Melanoma Database and Discovery PlatformMelanoma staging: evidence-based changes in the American joint committee on cancer eighth edition cancer staging manual. CA Cancer J Clin 2017;67:472-492.
Ethun CG, Delman KA. The importance of surgical margins in melanoma. J Surg Oncol 2016;113:339-345.
Gidley PW, Roberts DB, Sturgis EM. Squamous cell carcinoma of the temporal bone. Laryngoscope 2010;120:1144-1151.
Muelleman T, Chowdhury NI, Killeen D, et al. Effect of piecemeal vs en bloc approaches to the lateral temporal bone on survival outcomes. Otolaryngol Head Neck Surg 2018;158:716-720.
Breen JT, Roberts DB, Gidley PW. Basal cell carcinoma of the temporal bone and external auditory canal. Laryngoscope 2018;128:1425-1430.
Zhang T, Li W, Dai C, Chi F, Wang S, Wang Z. Evidence-based surgical management of T1 or T2 temporal bone malignancies. Laryngoscope 2013;123:244-248.
Morris LGT, Mehra S, Shah JP, Bilsky MH, Selesnick SH, Kraus DH. Predictors of survival and recurrence after temporal bone resection for cancer. Head Neck 2012;34:1231-1239.
Frost J, Dunne JA, Powell BW. External ear melanoma: a 10 year assessment of management and outcomes. J Plast Reconstr Aesthet Surg 2017;70:551-552.
Rouvière H. Anatomie des Lymphatiques de L'Homme. France; Masson: Issy-les-Moulineaux; 1932.
Adler NR, Haydon A, McLean CA, Kelly JW, Mar VJ. Metastatic pathways in patients with cutaneous melanoma. Pigment Cell Melanoma Res 2017;30:13-27.
Morton DL, Thompson JF, Cochran AJ. et al; MSLT GroupFinal trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med 2014;370:599-609.
Faries MB, Thompson JF, Cochran AJ, et al. Completion dissection or observation for sentinel-node metastasis in melanoma. N Engl J Med 2017;376:2211-2222.
Erman AB, Collar RM, Griffith KA, et al. Sentinel lymph node biopsy is accurate and prognostic in head and neck melanoma. Cancer 2012;118:1040-1047.
NCCN Guidelines for Cutaneous Melanoma. Plymouth Meeting, PA: National Comprehensive Cancer Network; 2019.
Fort M, Guet S, Husheng S, Calitchi E, Belkacemi Y. Role of radiation therapy in melanomas: systematic review and best practice in 2016. Crit Rev Oncol Hematol 2016;99:362-375.
Li W, Yu Y, Wang H, Yan A, Jiang X. Evaluation of the prognostic impact of postoperative adjuvant radiotherapy on head and neck mucosal melanoma: a meta-analysis. BMC Cancer 2015;15:758.
Burmeister BH, Henderson MA, Ainslie J, et al. Adjuvant radiotherapy versus observation alone for patients at risk of lymph-node field relapse after therapeutic lymphadenectomy for melanoma: a randomised trial. Lancet Oncol 2012;13:589-597.
Hwu P. Treating cancer by targeting the immune system. N Engl J Med 2010;363:779-781.
Chambers CA, Kuhns MS, Egen JG, Allison JP. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol 2001;19:565-594.
Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with Ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-723.
Weber J, Mandala M, Del Vecchio M, et al. Adjuvant nivolumab versus ipilimumab in resected stage iii or iv melanoma. N Engl J Med 2017;377:1824-1835.
Friedmann I, Radcliffe A. Otosclerosis associated with malignant melanoma of the ear. The Journal of Laryngology & Otology 1954; 68:114-119.
Lederman M. Malignant tumours of the ear. The Journal of Laryngology & Otology 1965; 79:85-119.
Shih, Lucy, James A. Crabtree. Carcinoma of the external auditory canal: an update. The Laryngoscope 1990; 100:1215-1218.