A Ninhydrin-Type Urea Sorbent for the Development of a Wearable Artificial Kidney.
chemisorption
dialysis
ninhydrin
sorbent
urea
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
18
11
2019
revised:
09
01
2020
pubmed:
18
2
2020
medline:
6
1
2021
entrez:
18
2
2020
Statut:
ppublish
Résumé
The aim of this study is to develop polymeric chemisorbents with a high density of ninhydrin groups, able to covalently bind urea under physiological conditions and thus potentially suitable for use in a wearable artificial kidney. Macroporous beads are prepared by suspension polymerization of 5-vinyl-1-indanone (vinylindanone) using a 90:10 (v/v) mixture of toluene and nitrobenzene as a porogen. The indanone groups are subsequently oxidized in a one-step procedure into ninhydrin groups. Their urea absorption kinetics are evaluated under both static and dynamic conditions at 37 °C in simulated dialysate (urea in phosphate buffered saline). Under static conditions and at a 1:1 molar ratio of ninhydrin: urea the sorbent beads remove ≈0.6-0.7 mmol g
Identifiants
pubmed: 32065727
doi: 10.1002/mabi.201900396
doi:
Substances chimiques
Urea
8W8T17847W
Ninhydrin
HCL6S9K23A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900396Informations de copyright
© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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