The functional connectivity profile of tics and obsessive-compulsive symptoms in Tourette Syndrome.
Functional connectivity
Obsessive-compulsive symptoms
Sensorimotor cortex
Sensory phenomena
Tourette syndrome
fMRI
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
09
12
2019
revised:
24
01
2020
accepted:
29
01
2020
pubmed:
18
2
2020
medline:
15
5
2021
entrez:
18
2
2020
Statut:
ppublish
Résumé
Tourette Syndrome (TS) is characterized by the presence of tics and sensory phenomena, such as premonitory urges, and is often accompanied by significant obsessive-compulsive symptoms (OCS). The goal of this exploratory study was to determine the association between functional connectivity and the different symptom domains of TS, as little is currently known about how they differ. Resting-state functional magnetic resonance imaging was performed in 39 patients with TS and 20 matched healthy controls. Seed-based functional connectivity of the supplementary motor area (SMA), orbitofrontal cortex (OFC), insula, caudate and putamen were compared between the groups, and correlated with clinical measures within the patient group. When compared to controls, patients with TS exhibited greater connectivity between the temporal gyri, insula and putamen, and between the OFC and cingulate cortex. Tic severity was associated with greater connectivity between the putamen and the sensorimotor cortex; OCS severity was associated with less connectivity between the SMA and thalamus and between the caudate and precuneus; and premonitory urge severity was associated with less connectivity between the OFC and sensorimotor cortex and between the inferior frontal gyrus and the putamen and insula seeds. Functional connectivity within sensorimotor processing regions were associated with all of the investigated symptom domains, including OCS, suggesting dysfunctions in the sensorimotor system may explain most of the observed symptoms in TS, and not just tics.
Identifiants
pubmed: 32065948
pii: S0022-3956(19)31321-4
doi: 10.1016/j.jpsychires.2020.01.019
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
128-135Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest Dr. Arnold receives support from the Alberta Innovates Translational Health Chair in Child and Youth Mental Health. Dr. Sandor receives grant funding from the Tourette Syndrome Association for an unrelated study. All other authors have no declarations of interest.